A Class Activation Map-Based Interpretable Transfer Learning Model for Automated Detection of ADHD from fMRI Data

Automatic detection of Attention Deficit Hyperactivity Disorder (ADHD) based on the functional Magnetic Resonance Imaging (fMRI) through Deep Learning (DL) is becoming a quite useful methodology due to the curse of-dimensionality problem of the data is solved. Also, this method proposes an invasive...

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Bibliographic Details
Published in:Clinical EEG and neuroscience 2023-03, Vol.54 (2), p.151-159
Main Authors: Uyulan, Caglar, Erguzel, Turker Tekin, Turk, Omer, Farhad, Shams, Metin, Baris, Tarhan, Nevzat
Format: Article
Language:English
Subjects:
Attention Deficit Disorder with Hyperactivity
Attention deficit hyperactivity disorder
Brain
Brain mapping
Child
Data acquisition
Deep learning
Electroencephalography
Functional magnetic resonance imaging
Humans
Machine Learning
Magnetic Resonance Imaging - methods
Neural networks
Neuroimaging
Transfer learning
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Summary:Automatic detection of Attention Deficit Hyperactivity Disorder (ADHD) based on the functional Magnetic Resonance Imaging (fMRI) through Deep Learning (DL) is becoming a quite useful methodology due to the curse of-dimensionality problem of the data is solved. Also, this method proposes an invasive and robust solution to the variances in data acquisition and class distribution imbalances. In this paper, a transfer learning approach, specifically ResNet-50 type pre-trained 2D-Convolutional Neural Network (CNN) was used to automatically classify ADHD and healthy children. The results demonstrated that ResNet-50 architecture with 10-k cross-validation (CV) achieves an overall classification accuracy of 93.45%. The interpretation of the results was done via the Class Activation Map (CAM) analysis which showed that children with ADHD differed from controls in a wide range of brain areas including frontal, parietal and temporal lobes.
ISSN:1550-0594
2169-5202
DOI:10.1177/15500594221122699