High plasma homocysteine level is associated with increased prevalence of the non-remission state in rheumatoid arthritis: Findings from the KURAMA cohort

ABSTRACT Objectives We aimed to determine the clinical impact of plasma homocysteine levels on disease activity and clinical remission in patients with rheumatoid arthritis (RA). Methods A cross-sectional study was conducted using KURAMA (Kyoto University Rheumatoid Arthritis Management Alliance) da...

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Published in:Modern rheumatology 2023-08, Vol.33 (5), p.911-917
Main Authors: Katsushima, Masao, Minamino, Hiroto, Shirakashi, Mirei, Onishi, Akira, Fujita, Yoshihito, Yamamoto, Wataru, Onizawa, Hideo, Tsuji, Hideaki, Watanabe, Ryu, Murakami, Kosaku, Fujii, Takayuki, Murata, Koichi, Tanaka, Masao, Inagaki, Nobuya, Morinobu, Akio, Hashimoto, Motomu
Format: Article
Language:English
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Summary:ABSTRACT Objectives We aimed to determine the clinical impact of plasma homocysteine levels on disease activity and clinical remission in patients with rheumatoid arthritis (RA). Methods A cross-sectional study was conducted using KURAMA (Kyoto University Rheumatoid Arthritis Management Alliance) database. We enrolled 291 female patients, who were treated in a treat-to-target manner. We measured plasma total homocysteine using a liquid chromatography–tandem mass spectrometry system and collected clinical data including a 28-joint RA disease activity score-erythrocyte sedimentation rate (DAS28-ESR). Clinical remission of disease activity was defined as a DAS28-ESR 
ISSN:1439-7595
1439-7609
DOI:10.1093/mr/roac106