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Examining selection bias in a population-based cohort study of 522 children with familial high risk of schizophrenia or bipolar disorder, and controls: The Danish High Risk and Resilience Study VIA 7

Purpose Knowledge about representativity of familial high-risk studies of schizophrenia and bipolar disorder is essential to generalize study conclusions. The Danish High Risk and Resilience Study (VIA 7), a population-based case–control familial high-risk study, creates a unique opportunity for com...

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Published in:Social Psychiatry and Psychiatric Epidemiology 2023, Vol.58 (1), p.113-140
Main Authors: Krantz, Mette Falkenberg, Hjorthøj, Carsten, Ellersgaard, Ditte, Hemager, Nicoline, Christiani, Camilla, Spang, Katrine Søborg, Burton, Birgitte Klee, Gregersen, Maja, Søndergaard, Anne, Greve, Aja, Ohland, Jessica, Mortensen, Preben Bo, Plessen, Kerstin Jessica, Bliksted, Vibeke, Jepsen, Jens Richardt Møllegaard, Thorup, Anne A. E., Mors, Ole, Nordentoft, Merete
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Language:English
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Summary:Purpose Knowledge about representativity of familial high-risk studies of schizophrenia and bipolar disorder is essential to generalize study conclusions. The Danish High Risk and Resilience Study (VIA 7), a population-based case–control familial high-risk study, creates a unique opportunity for combining assessment and register data to examine cohort representativity. Methods Through national registers, we identified the population of 11,959 children of parents with schizophrenia (FHR-SZ) or bipolar disorder (FHR-BP) and controls from which the 522 children participating in The VIA 7 Study (202 FHR-SZ, 120 FHR-BP and 200 controls) were selected. Socio-economic and health data were obtained to compare high-risk groups and controls, and participants versus non-participants. Selection bias impact on results was analyzed through inverse probability weights. Results In the total sample of 11,959 children, FHR-SZ and FHR-BP children had more socio-economic and health disadvantages than controls ( p  
ISSN:0933-7954
1433-9285
DOI:10.1007/s00127-022-02338-3