Stress hyperglycaemia or diabetes mellitus in cervicofacial infections? a Maxillofacial Surgery Trainee Research Collaborative (MTReC) study

Diabetes mellitus (DM) is thought to be associated with poor outcomes in cervicofacial infections (CFI), yet little is known about the prevalence of DM in these cases. Stress hyperglycaemia (SHG), a normal physiological response to inflammation, is distinct from DM, though they overlap and may be co...

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Published in:British journal of oral & maxillofacial surgery 2022-10, Vol.60 (8), p.1049-1055
Main Authors: Kent, Samuel, Dawoud, Basim, Henry, Alastair, McDonald, Chris, Hennedige, Anusha, Kulkarni, Raghav, Logan, Greg, Exley, Rebecca, Kyzas, Panos, Morrison, Roderick, McCaul, James, Brandsma, Dirk Stephanus, Cashman, Helen, Swain, Aoife, Java, Kapil, Vithlani, Gauri, Watson, Melanie, Christopher, Mark, Murray, Susan, Baniulyte, Gabriele, Grant, Jamie, Wareing, Sam, Kawalec, Alex, Ng, Teresa, Reedy, Nagarjuna, Tavakoli, Milad, Underwood, Charlotte, Gowrishankar, Siddharth, Collins, Tim, Davies, Rhodri, Uppal, Sharonjeet, Elledge, Ross, Shaheen, Syca, O’Connor, Rory, King, Hudson, Tudor-Green, Ben, Garg, Montey, Wareing, Jonathan, Wicks, Catherine, Mitchell, Oliver, Maarouf, Marwa, Chohan, Priya, Otukoya, Rachael, Wu, Eiling, Farooq, Saadia, Brewer, Esther, King, Samuel, Nandra, Baljeet, Stevenson, Sam, Stiles, Ellis, Davies, Laurie, Madattigowda, Ramachandra, Mohindra, Aneesh
Format: Article
Language:English
Subjects:
Cervicofacial infection
Diabetes Mellitus
Length of stay
Odontogenic infection
Stress Hyperglycaemia
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Summary:Diabetes mellitus (DM) is thought to be associated with poor outcomes in cervicofacial infections (CFI), yet little is known about the prevalence of DM in these cases. Stress hyperglycaemia (SHG), a normal physiological response to inflammation, is distinct from DM, though they overlap and may be conflated. We aimed to establish the prevalence of DM and SHG in CFI, and to determine the effect of each on severity of disease and outcome measures. The Maxillofacial Surgery Trainee Research Collaborative (MTReC) carried out an audit of all patients with CFI admitted to 25 hospitals between May and October 2017. To the best of our knowledge this created the largest prospective database on CFI, with information collected on presentation, source of infection, biological data, and outcomes. We recorded 1002 admissions, of which 78 (7.8%) had DM. Random blood glucose was measured on admission in 401 patients (40%), of which 45 (11%) displayed SHG. Patients diagnosed with DM were more likely to have infections arising from a salivary source (13% vs 4%, p 
ISSN:0266-4356
1532-1940
DOI:10.1016/j.bjoms.2021.01.020