Levofloxacin in nanostructured lipid carriers: Preformulation and critical process parameters for a highly incorporated formulation

[Display omitted] The first step of a successful nanoformulation development is preformulation studies, in which the best excipients, drug-excipient compatibility and interactions can be identified. During the formulation, the critical process parameters and their impact must be studied to establish...

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Bibliographic Details
Published in:International journal of pharmaceutics 2022-10, Vol.626, p.122193-122193, Article 122193
Main Authors: Beraldo-Araújo, Viviane Lucia, Flávia Siqueira Vicente, Ana, van Vliet Lima, Marcelo, Umerska, Anita, Souto, Eliana B., Tajber, Lidia, Oliveira-Nascimento, Laura
Format: Article
Language:English
Subjects:
Degradation
Design of experiments
Levofloxacin
Nanostructured lipid carrier
Preformulation
Solid state
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Summary:[Display omitted] The first step of a successful nanoformulation development is preformulation studies, in which the best excipients, drug-excipient compatibility and interactions can be identified. During the formulation, the critical process parameters and their impact must be studied to establish the stable system with a high drug entrapment efficiency (EE). This work followed these steps to develop nanostructured lipid carriers (NLCs) to deliver the antibiotic levofloxacin (LV). The preformulation studies covered drug solubility in excipients and thorough characterization using thermal analysis, X-ray diffraction and spectroscopy. A design of experiment based on the process parameters identified nanoparticles with 
ISSN:0378-5173
1873-3476
DOI:10.1016/j.ijpharm.2022.122193