Clinical relevance of multiple confirmed preserved ratio impaired spirometry cases in adults

Preserved ratio impaired spirometry (PRISm) is a common spirometry finding, but its heterogeneous manifestations and frequent transitions to airflow limitation (AFL), chronic obstructive pulmonary disease, or normal spirometry hinder establishing an appropriate management strategy. This study examin...

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Bibliographic Details
Published in:Respiratory investigation 2022-11, Vol.60 (6), p.822-830
Main Authors: Tanabe, Naoya, Masuda, Izuru, Shiraishi, Yusuke, Maetani, Tomoki, Hamada, Satoshi, Sato, Atsuyasu, Sato, Susumu, Hirai, Toyohiro
Format: Article
Language:English
Subjects:
Airflow limitation
Chronic obstructive pulmonary disease
Preserved ratio impaired spirometry
Spirometry
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Summary:Preserved ratio impaired spirometry (PRISm) is a common spirometry finding, but its heterogeneous manifestations and frequent transitions to airflow limitation (AFL), chronic obstructive pulmonary disease, or normal spirometry hinder establishing an appropriate management strategy. This study examined whether transition to AFL and baseline comorbidities are more frequent in subjects with definite PRISm (PRISm confirmed on both current and past two spirometry tests) versus incident PRISm (PRISm confirmed only on a current test with past normal spirometry records) than in normal spirometry. Archived medical check-up data of subjects aged ≥40 years (n = 10828) with two past spirometry records, in a Japanese hospital, were cross-sectionally analyzed. Among them, data from those with follow-up spirometry after three years (n = 6467) were used to evaluate transition to AFL. PRISm was defined as forced volume in 1 s (FEV1)/forced vital capacity ≥0.7 and % predicted FEV1 
ISSN:2212-5345
2212-5353
DOI:10.1016/j.resinv.2022.08.006