Locus coeruleus degeneration and cerebellar gray matter changes in essential tremor

Background The pathophysiology of essential tremor (ET) is not fully understood, and studies suggest pathological changes mainly occur in the cerebellum and locus coeruleus (LC). Methods Fifty-three ET patients, including 30 patients with head tremor (h-ET), 23 patients without head tremor (nh-ET),...

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Bibliographic Details
Published in:Journal of neurology 2023-02, Vol.270 (2), p.780-787
Main Authors: Lv, Dayao, Zhou, Cheng, Pu, Jiali, Lu, Jinyu, Zhao, Gaohua, Gu, Luyan, Guan, Xiaojun, Guo, Tao, Xu, Xiaojun, Zhang, Minming, Tian, Jun, Yin, Xinzhen, Zhang, Baorong, Zhao, Guohua, Yan, Yaping
Format: Article
Language:English
Subjects:
Atrophy
Cerebellum
Cerebellum - diagnostic imaging
Cerebellum - pathology
Degeneration
Essential Tremor - diagnostic imaging
Essential Tremor - pathology
Gray Matter - diagnostic imaging
Gray Matter - pathology
Humans
Locus coeruleus
Locus Coeruleus - diagnostic imaging
Locus Coeruleus - pathology
Magnetic resonance imaging
Magnetic Resonance Imaging - methods
Medicine
Medicine & Public Health
Neurology
Neuroradiology
Neurosciences
Original Communication
Pathophysiology
Substantia grisea
Tremor
Tremor (Muscular contraction)
Tremor - pathology
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Summary:Background The pathophysiology of essential tremor (ET) is not fully understood, and studies suggest pathological changes mainly occur in the cerebellum and locus coeruleus (LC). Methods Fifty-three ET patients, including 30 patients with head tremor (h-ET), 23 patients without head tremor (nh-ET), 71 age and education matched healthy controls (HCs) were enrolled. All participants underwent Neuromelanin-sensitive magnetic resonance imaging (NM-MRI) and T1 scans on a 3-Tesla MR system. Next, we assessed the relationship between the contrast-to-noise ratio of LC (CNR LC ) and the score of The Essential Tremor Rating Assessment Scale (TETRAS) and cerebellum gray matter (GM) volume. Results Significant difference of CNR LC was found between ET and HC groups. The CNR LC of ET groups is lower than the HC group ( p  = 0.031). Subgroup analysis showed that the CNR LC in nh-ET was significantly lower than HCs ( p  = 0.016). Compared to HCs, h-ETs showed marked atrophy in the cerebellum: the vermis IV–V and lobule VI (GRF corrected, p  
ISSN:0340-5354
1432-1459
DOI:10.1007/s00415-022-11409-z