Label-free fibre optic Raman spectroscopy with bounded simplex-structured matrix factorization for the serial study of serum in amyotrophic lateral sclerosis

Amyotrophic lateral sclerosis (ALS) is an incurable neurodegenerative disease in urgent need of disease biomarkers for the assessment of promising therapeutic candidates in clinical trials. Raman spectroscopy is an attractive technique for identifying disease related molecular changes due to its sim...

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Bibliographic Details
Published in:Analyst (London) 2022-11, Vol.147 (22), p.5113-512
Main Authors: Alix, James J. P, Verber, Nick S, Schooling, Chlöe N, Kadirkamanathan, Visakan, Turner, Martin R, Malaspina, Andrea, Day, John C. C, Shaw, Pamela J
Format: Article
Language:English
Subjects:
Amyotrophic lateral sclerosis
Amyotrophic Lateral Sclerosis - diagnosis
Amyotrophic Lateral Sclerosis - metabolism
Biomarkers
C-Reactive Protein
Chemistry
Factorization
Humans
Neurodegenerative Diseases
Proteins
Raman spectra
Raman spectroscopy
Spectrum analysis
Spectrum Analysis, Raman
Structured matrices
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