Deep brain stimulation in obsessive-compulsive disorder: Results from meta-analysis

•The first line of treatment in Obssesive compulsive disorder (OCD) is selective serotonin re-uptake inhibitor in combination with cognitive behavioral therapy and physical procedures are reserved for these cases. Deep brain stimulation (DBS) is a technique that affects cortico-striated-thalamus-cor...

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Published in:Psychiatry research 2022-11, Vol.317, p.114869-114869, Article 114869
Main Authors: Cruz, Sheila, Gutiérrez-Rojas, Luis, González-Domenech, Pablo, Díaz-Atienza, Francisco, Martínez-Ortega, José M., Jiménez-Fernández, Sara
Format: Article
Language:English
Subjects:
Anxiety
Deep brain stimulation
Deep Brain Stimulation - methods
Depression
Humans
Meta-analysis
Obsessive compulsive disorder
Obsessive-Compulsive Disorder - diagnosis
Treatment Outcome
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Summary:•The first line of treatment in Obssesive compulsive disorder (OCD) is selective serotonin re-uptake inhibitor in combination with cognitive behavioral therapy and physical procedures are reserved for these cases. Deep brain stimulation (DBS) is a technique that affects cortico-striated-thalamus-cortical circuit fiber through the implantation of an electrical device on a cerebral target.•This meta-analytical work focuses on the assessment of the efficacy of DBS in resistant and severe patients with Obssesive compulsive disorder (OCD). We demonstrate that this technique improves obsessive compulsive behavior and functionality.•Moreover, DBS in resistant and severe patients with Obssesive compulsive disorder (OCD) reduce depression and anxiety symptoms measured by standardized scales. The aim of this work is to investigate the effectiveness of Deep Brain Stimulation (DBS) in patients with severe Obsessive Compulsive Disorder (OCD) who are resistant to pharmacological treatments, focusing on obsessive compulsive, depressive and anxiety symptoms as well as global function. A systematic review and meta-analysis including 25 studies (without language restrictions) from between 2003 and 2020 was performed. A total of 303 patients were evaluated twice (before and after DBS). After DBS treatment OCD patients with resistance to pharmacological treatments showed a significant improvement of obsessive-compulsive symptoms (25 studies; SMD=2.39; 95% CI, 1.91 to 2.87; P
ISSN:0165-1781
1872-7123
DOI:10.1016/j.psychres.2022.114869