Approach to ureteral endometriosis: A single‐center experience and meta‐analysis of the literature

• Published in: The journal of obstetrics and gynaecology research 2023-01, Vol.49 (1), p.75-89
• Main Authors: Alborzi, Saeed, Askary, Elham, Poordast, Tahereh, Alborzi, Soroosh, Abadi, Alimohammad K. H., Shoaii, Fatemeh
• Format: Article
• Language: English
• Subjects: Clavien–Dindo classification; Cross-Sectional Studies; Endometriosis; Endometriosis - complications; Endometriosis - pathology; Endometriosis - surgery; Female; Hematuria; Humans; Laparoscopy; Laparoscopy - methods; Meta-analysis; Pain; perioperative complication; postoperative pain; Retrospective Studies; Stenosis; Surgery; Treatment Outcome; Ureteral Diseases - surgery; Urinary tract
• ISSN: 1341-8076; 1447-0756
• DOI: 10.1111/jog.15449

Aim To report single‐center outcomes of laparoscopic management of patients with ureteral endometriosis and perform a meta‐analysis in order to select the best approach for these patients. Methods The cross‐sectional study was conducted during a 6‐year period (2015–2021) in the referral endometriosis center on 353 patients with ureteral endometriosis. For the meta‐analysis, 10 articles, including 505 patients, were found to be eligible. In our meta‐analysis, as well as our study, all endometriosis‐related pain symptoms and complications of surgery were evaluated, analyzed, and reported. Results Of the 326 patients whose ureteral involvement was confirmed in pathology, hydronephrosis and intrinsic ureteral lesions were detected in only 10.76% and 3.1% of the patients. Mean operating time and hospitalization were 3.25 ± 1.83 h and 86 ± 2.58 days, respectively. The most common site of concomitant involvement with endometriosis was uterosacral ligament (92.9%) and rectosigmoid (70.53%). Type II and III of Cliven–Dindo complications were seen in 5.66% and 1.13% of patients, respectively. During a follow‐up period, no evidence of bladder or ureteral re‐involvement was observed. Similar to our meta‐analysis, all endometriosis‐related pain decreased significantly following operation (p ≤ 0.001). In our meta‐analysis, the rate of ureteral endometriosis recurrence, stenosis/stricture, bladder atonia, urinary tract infection, hematuria, and fistula formation after surgery were: 2.0% (I2: 50.42%), 15.0% (I2: 0.00%), 14.0% (I2: 8.76%), 6.0% (I2: 0.00%), 7.0% (I2: 79.28%), and 2.0% (I2: 0.0%), respectively. Conclusion The laparoscopic resection of the UE could be suggested as a feasible and safe method associated with favorable functional outcomes.