Infants Born Following SARS-CoV-2 Infection in Pregnancy

• Published in: Pediatrics (Evanston) 2022-11, Vol.150 (5), p.1
• Main Authors: Capretti, Maria Grazia, Marsico, Concetta, Gabrielli, Liliana, Vocale, Caterina, Arcuri, Santo, Simonazzi, Giuliana, Piccinini, Anna Rita, Brandolini, Cristina, Lazzarotto, Tiziana, Corvaglia, Luigi Tommaso
• Format: Article
• Language: English
• Subjects: Cesarean section; Coronaviruses; Immunity (passive); Immunoglobulin G; Immunoglobulin M; Immunoglobulins; Infants; Infections; Mothers; Neonates; Pediatrics; Placental transfer; Pregnancy; Severe acute respiratory syndrome coronavirus 2; Spike protein
• ISSN: 0031-4005; 1098-4275
• DOI: 10.1542/peds.2022-056206

OBJECTIVES To evaluate outcomes of neonates born to mothers with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection during pregnancy, the dynamics of placental transfer of maternal antibodies, and its persistence during infancy. METHODS Cohort study enrolling neonates born to mothers with SARS-CoV-2 infection in pregnancy. All infants were evaluated at birth. Those born to women with infection onset within 2 weeks before delivery were excluded from further analyses. Remaining infants underwent cerebral and abdominal ultrasound, fundoscopy evaluation, and were enrolled in a 12 month follow-up. Qualitative immunoglobulin G (IgG)/immunoglobulin M and quantitative IgG to S1/S2 subunits of spike protein were assessed in mother–neonate dyads within 48 hours postdelivery and during follow-up. RESULTS Between April 2020 and April 2021, 130 of 2745 (4.7%) neonates were born to mothers with SARS-CoV-2 infection in pregnancy, with 106 of 130 infections diagnosed before 2 weeks before delivery. Rates of preterm and cesarean delivery were comparable between women with and without infection (6% vs 8%, P = .57; 22% vs 32%, P = .06). No clinical or instrumental abnormalities were detected at birth or during follow-up. There was a positive correlation between maternal and neonatal SARS-CoV-2 IgG levels (r = 0.81, P < .001). Transplacental transfer ratio was higher after second-trimester maternal infections as compared with first and third trimester (P = .03). SARS-CoV-2 IgG level progressively decreased in all infants, with 89 of 92 (97%) infants seronegative at 6 months of age. CONCLUSIONS Clinical outcomes were favorable in all infants. Matching peak IgG level after infection and higher IgG transplacental transfer might result in the most durable neonatal passive immunity.