Risk and preventive factors of early‐onset colorectal neoplasms: endoscopic and histological database analysis

• Published in: Journal of gastroenterology and hepatology 2023-02, Vol.38 (2), p.259-268
• Main Authors: Arai, Junya, Aoki, Tomonori, Hayakawa, Yoku, Niikura, Ryota, Ishibashi, Rei, Suzuki, Nobumi, Tsuji, Yosuke, Yamada, Atsuo, Ushiku, Tetsuo, Fujishiro, Mitsuhiro
• Format: Article
• Language: English
• Subjects: Adenocarcinoma; Adenoma; Adenoma - pathology; Age; Colonoscopy; Colonoscopy - adverse effects; Colorectal cancer; Colorectal carcinoma; Colorectal Neoplasms - pathology; Dysplasia; early‐onset colorectal neoplasms; family history; Family medical history; Humans; Male; Middle Aged; Retrospective Studies; Risk Factors; Sex ratio; Tumors
• ISSN: 0815-9319; 1440-1746
• DOI: 10.1111/jgh.16045

Background and Aim The incidence of early‐onset colorectal neoplasms has been increasing in both Western and Eastern countries. However, the risks and preventive factors for these neoplasms in Eastern countries remain unclear. Methods The data of 5580 patients who underwent colonoscopy between 2016 and 2021 were retrospectively evaluated. The primary outcome was advanced colorectal neoplasm (ACRN), defined as advanced adenomas (adenoma ≥10 mm, or with high‐grade dysplasia or villous component) or adenocarcinoma. The clinical factors associated with ACRNs were determined for each age category (≤50 and >50 years), and the differences between the two categories were assessed. Odds ratios adjusted for age and sex were calculated. Results Among 1001 patients (age ≤50 years), ACRN was found in 94 (9.4%). In this younger category, male sex (adjusted odds ratio [aOR]:2.34, 95% confidence interval [CI]:1.51–3.63) and a family history of colorectal cancer (aOR:2.14, 95% CI:1.17–3.89) were significantly associated with higher odds of developing ACRNs. ACRNs were detected in 726 (15.9%) of 4579 patients (age >50 years). In the older age category, smoking (aOR:1.32, 95% CI:1.08–1.63) was significantly associated with a higher risk of ACRNs. Exercise of >3.5 metabolic equivalent of task (METs) (aOR,0.80; 95% CI:0.67–0.96) was significantly associated with a lower risk of ACRNs. Conclusion The development of early‐onset ACRNs was primarily associated with congenital factors, whereas that of late‐onset ACRNs was associated with acquired ones. Colonoscopy is recommended for young male patients, particularly for those with a family history of colorectal cancer.