Neutrophil to lymphocyte ratio (NLR) impact on the progression-free survival and overall survival of multiple myeloma patients treated with high-dose chemotherapy and autologous stem cell transplantation

High-dose chemotherapy with autologous stem-cell transplantation (ASCT) remains the standard of care in multiple myeloma (MM) patients. This retrospective study aimed to assess the impact of neutrophil-to-lymphocyte ratio (NLR) and other complete blood count (CBC)-based predictors on PFS and OS of t...

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Published in:Leukemia & lymphoma 2023-01, Vol.64 (1), p.98-106
Main Authors: Mikulski, Damian, Kościelny, Kacper, Nowicki, Mateusz, Wawrzyniak, Ewa, Kalwas, Marta, Kowalik, Monika, Pryt, Mateusz, Sęczkowska, Emilia, Świątek, Agnieszka, Wierzbowska, Agnieszka, Fendler, Wojciech
Format: Article
Language:English
Subjects:
Antineoplastic Combined Chemotherapy Protocols - adverse effects
Autologous stem cell transplantation
Disease-Free Survival
Hematopoietic Stem Cell Transplantation
Humans
Lymphocytes
multiple myeloma
Multiple Myeloma - drug therapy
Multiple Myeloma - therapy
neutrophil-to-lymphocyte ratio
Neutrophils
plasma cell myeloma
Progression-Free Survival
Retrospective Studies
Stem Cell Transplantation
Transplantation, Autologous
Treatment Outcome
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Summary:High-dose chemotherapy with autologous stem-cell transplantation (ASCT) remains the standard of care in multiple myeloma (MM) patients. This retrospective study aimed to assess the impact of neutrophil-to-lymphocyte ratio (NLR) and other complete blood count (CBC)-based predictors on PFS and OS of transplant-eligible MM patients. The CBC-based biomarkers were evaluated in a single-center cohort of 176 MM patients at three time points: at the diagnosis, the time of ASCT, and +100 d after ASCT. Univariable and multivariable Cox's regression analyses and Kaplan-Meier estimate were used in statistical analysis. NLR at ASCT (HR 1.15, 95% CI: 1.05-1.26) and hemoglobin at ASCT (HR 0.80, 95% CI: 0.68-0.94) were independent factors influencing PFS. In the model for OS, the only statistically significant factors were NLR at ASCT (HR 1.15, 95% CI: 1.04-1.27), bortezomib administration prior to ASCT (HR 0.52, 95% CI: 0.33-0.83) and age at diagnosis (HR 1.03, 95% CI: 1.00-1.06). NLR at ASCT is an independent predictive factor in MM patients undergoing ASCT.
ISSN:1042-8194
1029-2403
DOI:10.1080/10428194.2022.2136946