Evaluation of the direction and extent of ice formation during cryoballoon ablation: an experimental study

• Published in: Journal of interventional cardiac electrophysiology 2023-06, Vol.66 (4), p.981-989
• Main Authors: Mizutani, Yoshiaki, Yanagisawa, Satoshi, Fujiwara, Gen, Kasai, Yosuke, Tajima, Atomu, Makino, Yuichiro, Suzuki, Hitomi, Hiramatsu, Takatsugu, Ichimiya, Hitoshi, Uchida, Yasuhiro, Watanabe, Junji, Kanashiro, Masaaki, Inden, Yasuya, Murohara, Toyoaki
• Format: Article
• Language: English
• Subjects: Ablation; Animals; Atrial Fibrillation - surgery; Balloons; Cardiology; Catheter Ablation; Cryosurgery; Heart Atria - surgery; Horizontal orientation; Ice; Ice formation; Medicine; Medicine & Public Health; Polar environments; Pulmonary Veins - surgery; Saline solutions; Swine; Treatment Outcome
• ISSN: 1572-8595; 1383-875X; 1572-8595
• DOI: 10.1007/s10840-022-01411-w

Background The distal hemisphere of a balloon is generally cooled during cryoapplication. However, a wide ablation area can be acquired after cryoballoon ablation. This study aimed to evaluate the extent of ice formation on two types of balloon surfaces through experimental and simulation studies. Methods A standard cryoballoon (SCB; Arctic Front Advance Pro, Medtronic) and novel cryoballoon (NCB; POLARx, Boston Scientific) were frozen for 240 s in 36 °C normal saline solution to observe ice formation on the balloon surface. Pieces of porcine tissue were placed between the upper and lower sides of the balloon, and the balloon was frozen in the horizontal direction for 240 s in 20 attempts (10 for SCB and NCB each). The measured areas of ice formation were evaluated and compared between the upper and lower sides of each balloon. Results Ice formation was greater on the lower side of the balloon than on the upper side. A larger area of ice formation in the tissue slab was observed on the lower side than on the upper side in both balloons, and the ice formation extended to the proximal hemisphere on the lower side of the balloon. The ice formation area in the NCB was significantly larger than that in SCB. Conclusions Ice formation was significantly greater on the lower side of the cryoballoon than on the upper side and extended to the proximal hemisphere of the balloon, which might facilitate the acquisition of a wide ablation area on the left atrial posterior wall after cryoballoon ablation. Graphical Abstract Different ice formation after cryoballoon ablation Greater ice formation on the lower side of cryoballoon and an extensive ice formation in the proximal hemisphere, especially in novel cryoballoon.