Fully automated CT-based adiposity assessment: comparison of the L1 and L3 vertebral levels for opportunistic prediction

• Published in: Abdominal imaging 2023-02, Vol.48 (2), p.787-795
• Main Authors: Liu, Daniel, Garrett, John W., Lee, Matt H., Zea, Ryan, Summers, Ronald M., Pickhardt, Perry J.
• Format: Article
• Language: English
• Subjects: Adipose tissue; Adiposity; Adult; Artificial Intelligence; Automation; Body fat; Cancer screening; Chest; Colorectal carcinoma; Computed tomography; Cross-Sectional Studies; Female; Gastroenterology; Hepatology; Humans; Imaging; Male; Medical screening; Medicine; Medicine & Public Health; Middle Aged; Mortality; Obesity; Quartiles; Radiology; Retrospective Studies; Survival; Technical; Tomography, X-Ray Computed - methods; Vertebrae; Women
• ISSN: 2366-0058; 2366-004X; 2366-0058
• DOI: 10.1007/s00261-022-03728-6

Purpose The purpose of this study is to compare fully automated CT-based measures of adipose tissue at the L1 level versus the standard L3 level for predicting mortality, which would allow for use at both chest (L1) and abdominal (L3) CT. Methods This retrospective study of 9066 asymptomatic adults (mean age, 57.1 ± 7.8 [SD] years; 4020 men, 5046 women) undergoing unenhanced low-dose abdominal CT for colorectal cancer screening. A previously validated artificial intelligence (AI) tool was used to assess cross-sectional visceral and subcutaneous adipose tissue areas (SAT and VAT), as well as their ratio (VSR) at the L1 and L3 levels. Post-CT survival prediction was compared using area under the ROC curve (ROC AUC) and hazard ratios (HRs). Results Median clinical follow-up interval after CT was 8.8 years (interquartile range, 5.2–11.6 years), during which 5.9% died (532/9066). No significant difference ( p >  0.05) for mortality was observed between L1 and L3 VAT and SAT at 10-year ROC AUC. However, L3 measures were significantly better for VSR at 10-year AUC ( p <  0.001). HRs comparing worst-to-best quartiles for mortality at L1 vs. L3 were 2.12 (95% CI, 1.65–2.72) and 2.22 (1.74–2.83) for VAT; 1.20 (0.95–1.52) and 1.16 (0.92–1.46) for SAT; and 2.26 (1.7–2.93) and 3.05 (2.32–4.01) for VSR. In women, the corresponding HRs for VSR were 2.58 (1.80–3.69) (L1) and 4.49 (2.98–6.78) (L3). Conclusion Automated CT-based measures of visceral fat (VAT and VSR) at L1 are predictive of survival, although overall measures of adiposity at L1 level are somewhat inferior to the standard L3-level measures. Utilizing predictive L1-level fat measures could expand opportunistic screening to chest CT imaging.