Severe Neurological Manifestation in a Child with Multisystem Inflammatory Syndrome

• Published in: Children (Basel, Switzerland) Switzerland), 2022, Vol.9 (11)
• Main Authors: Santos, Mônica de Oliveira, Ribeiro, Diuly Caroline, Rocha, Jordanna Sousa, Maia, Sibely Braga Santos, Moreira, André Luís Elias, Silva, Paulo Alex Neves, Ito, Célia Regina Malveste, Carneiro, Lilian Carla, Avelino, Melissa Ameloti Gomes
• Format: Report
• Language: English
• ISSN: 2227-9067; 2227-9067
• DOI: 10.3390/children9111653

BACKGROUND AND OBJECTIVESDuring the COVID-19 pandemic, we followed with concern the evolution of several children diagnosed with Multisystem Inflammatory Syndrome in Children (MIS-C). The purpose of this study is to describe the evolution of MIS-C in a previously healthy 3-year-old girl. METHODSWe tracked the daily medical report of all children admitted with suspected MIS-C to the five largest regional hospitals. RESULTSOur screening identified a child who had several neurological complications associated with MIS-C. We report hematological alterations, transient cardiac dysfunction, and cerebral involvements such as laminar cortical necrosis caused by ischemic stroke. We present the course of treatment and clinical outcome, and other complications such as a severe subglottic stenosis occurring after extubation. CONCLUSIONSubglottic stenosis is an expected complication after prolonged intubation, and the presence of dysphonia and/or stridor is an important predictive factor. MIS-C with severe neurological alteration may occur in a healthy child, and early diagnosis and treatment with a pulse of corticoid with immunoglobulin are essential for a favorable outcome.