The effect of probiotic and synbiotic use on glycemic control in women with gestational diabetes: A systematic review and meta-analysis

•Probiotics and/or synbiotics are promising as a potential therapy for GDM.•The use of probiotics in women with GDM decreased fasting plasma glucose.•The use of probiotics and synbiotics in women with GDM reduced HOMA-IR. To investigate the impact of probiotic/synbiotic use on glycemic control in wo...

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Bibliographic Details
Published in:Diabetes research and clinical practice 2022-12, Vol.194, p.110162-110162, Article 110162
Main Authors: Çetinkaya özdemir, Serap, küçüktürkmen Paşa, Büşra, Metin, Tuba, Dinçer, Berna, Sert, Havva
Format: Article
Language:English
Subjects:
Blood Glucose - analysis
Diabetes, Gestational - therapy
Dietary Supplements
Female
Gestational diabetes mellitus
Glycemic Control
Humans
Insulin - therapeutic use
meta-analysis
Pregnancy
probiotic
Probiotics - therapeutic use
synbiotic
Synbiotics
systematic review
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Summary:•Probiotics and/or synbiotics are promising as a potential therapy for GDM.•The use of probiotics in women with GDM decreased fasting plasma glucose.•The use of probiotics and synbiotics in women with GDM reduced HOMA-IR. To investigate the impact of probiotic/synbiotic use on glycemic control in women with gestational diabetes. We searched the PubMed, Medline, Scopus, ScienceDirect, Web of Science, Cochrane Central Register of Controlled Trials, Dergipark, and Council of Higher Education Thesis Center databases through March 2022. Screening was performed according to the population, intervention, comparison, outcome and study type. This systematic review and meta-analysis were performed in accordance with the Preferred Reporting Items for Systematic Review and Meta-analyses (PRISMA-2020) statement. Eight RCTs involving 551 patients were included in the meta-analysis. Probiotic use in women with gestational diabetes significantly decreased fasting blood glucose (mean difference: -1.43; 95% CI: -2.78 to -0.09, p: 0.04) and serum insulin (mean difference: -3.66; 95% CI: -5.04 to -2.27, p < 0.001). Moreover, the use of probiotics and synbiotics significantly reduced the HOMA-IR level compared to the control group (probiotic group: mean difference: -0.74; 95% CI: -1.05 to -0.44, p
ISSN:0168-8227
1872-8227
DOI:10.1016/j.diabres.2022.110162