Dendritic Quaternary‐Encoded Oligourethanes for Data Encryption

The use of sequence‐defined digital polymers for data storage and encryption has received increasing attention due to their precision structures similar to natural biomacromolecules (e.g., DNA) but increased stability. However, the rapid development of sequencing techniques raises the concern of inf...

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2023-01, Vol.62 (3), p.e202214695-n/a
Main Authors: Shi, Qiangqiang, Zhou, Xin, Xu, Jie, Zhang, Jialin, Wang, Ning, Zhang, Guoying, Hu, Jinming, Liu, Shiyong
Format: Article
Language:English
Subjects:
Cascade Depolymerization
Computer Security
Conformation
Data Encryption
Data storage
Dendritic structure
Deoxyribonucleic acid
DNA
Information Storage and Retrieval
Mass spectrometry
Mass spectroscopy
Oligourethane
Permutations
Polymers
Self-Immolative
Sequence-Encoded
Spectroscopy
Tandem Mass Spectrometry
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Summary:The use of sequence‐defined digital polymers for data storage and encryption has received increasing attention due to their precision structures similar to natural biomacromolecules (e.g., DNA) but increased stability. However, the rapid development of sequencing techniques raises the concern of information leakage. Herein, dendritic quaternary‐encoded oligourethanes bearing a photoresponsive trigger, self‐immolative backbones, and a mass spectrometry tag of PEG dendron have been developed for data encryption. Although the sequence information in linear analogs can be readily deciphered by mass spectrometry, sequencing of dendritic oligourethanes cannot be achieved by either primary MS or tandem MS/MS owing to the unique spatial conformation. Intriguingly, the fragmentation pathways of a quaternary dendrimer under MS/MS conditions can be converted to 2772‐bit 2D matrices with ≈1.98×1087 permutations, serving as high‐strength encryption keys for highly reliable data encryption. Dendritic quaternary‐encoded oligourethanes bearing self‐immolative linkages are developed for high‐strength data encryption. Specifically, the fragmentation paths of dendritic quaternary‐encoded oligourethanes under MALDI‐ToF MS/MS conditions can be translated into 2D matrices with ≈1.98×1087 permutations, and each 2772‐bit code 2D matrix can be further used as a unique decryption key to decipher the QR code for confidential communications.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.202214695