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Transcapillary escape rate of albumin in humans during exercise-induced hypervolemia
Andrew Haskell, Ethan R. Nadel, Nina S. Stachenfeld, Kei Nagashima, and Gary W. Mack The John B. Pierce Laboratory and Departments of Epidemiology and Public Health and of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut 06519 Received 16 December 1996; a...
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| Published in: | Journal of applied physiology (1985) 1997-08, Vol.83 (2), p.407-413 |
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| container_end_page | 413 |
| container_issue | 2 |
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| container_title | Journal of applied physiology (1985) |
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| creator | Haskell, Andrew Nadel, Ethan R Stachenfeld, Nina S Nagashima, Kei Mack, Gary W |
| description | Andrew
Haskell,
Ethan R.
Nadel,
Nina S.
Stachenfeld,
Kei
Nagashima, and
Gary W.
Mack
The John B. Pierce Laboratory and Departments of
Epidemiology and Public Health and of Cellular and Molecular
Physiology, Yale University School of Medicine, New Haven, Connecticut
06519
Received 16 December 1996; accepted in final form 2 April 1997.
Haskell, Andrew, Ethan R. Nadel, Nina S. Stachenfeld, Kei
Nagashima, and Gary W. Mack. Transcapillary escape rate of albumin
in humans during exercise-induced hypervolemia. J. Appl. Physiol. 83(2): 407-413, 1997. To test the
hypotheses that plasma volume (PV) expansion 24 h after intense
exercise is associated with reduced transcapillary escape rate of
albumin (TER alb ) and that local
changes in transcapillary forces in the previously active tissues favor
retention of protein in the vascular space, we measured PV,
TER alb , plasma colloid osmotic
pressure (COP p ), interstitial
fluid hydrostatic pressure (Pi), and colloid osmotic pressure in leg
muscle and skin and capillary filtration coefficient (CFC) in the arm
and leg in seven men and women before and 24 h after intense upright
cycle ergometer exercise. Exercise expanded PV by 6.4% at 24 h (43.9 ± 0.8 to 46.8 ± 1.2 ml/kg, P |
| doi_str_mv | 10.1152/jappl.1997.83.2.407 |
| format | article |
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Haskell,
Ethan R.
Nadel,
Nina S.
Stachenfeld,
Kei
Nagashima, and
Gary W.
Mack
The John B. Pierce Laboratory and Departments of
Epidemiology and Public Health and of Cellular and Molecular
Physiology, Yale University School of Medicine, New Haven, Connecticut
06519
Received 16 December 1996; accepted in final form 2 April 1997.
Haskell, Andrew, Ethan R. Nadel, Nina S. Stachenfeld, Kei
Nagashima, and Gary W. Mack. Transcapillary escape rate of albumin
in humans during exercise-induced hypervolemia. J. Appl. Physiol. 83(2): 407-413, 1997. To test the
hypotheses that plasma volume (PV) expansion 24 h after intense
exercise is associated with reduced transcapillary escape rate of
albumin (TER alb ) and that local
changes in transcapillary forces in the previously active tissues favor
retention of protein in the vascular space, we measured PV,
TER alb , plasma colloid osmotic
pressure (COP p ), interstitial
fluid hydrostatic pressure (Pi), and colloid osmotic pressure in leg
muscle and skin and capillary filtration coefficient (CFC) in the arm
and leg in seven men and women before and 24 h after intense upright
cycle ergometer exercise. Exercise expanded PV by 6.4% at 24 h (43.9 ± 0.8 to 46.8 ± 1.2 ml/kg, P < 0.05) and decreased total protein concentration (6.5 ± 0.1 to
6.3 ± 0.1 g/dl, P < 0.05) and
COP p (26.1 ± 0.8 to 24.3 ± 0.9 mmHg, P < 0.05), although plasma
albumin concentration was unchanged. TER alb tended to decline (8.4 ± 0.5 to 6.5 ± 0.7%/h, P = 0.11) and was correlated with the increase in PV
( r = 0.69,
P < 0.05). CFC increased in the leg
(3.2 ± 0.2 to 4.3 ± 0.5 µl · 100 g 1 · min 1 · mmHg 1 ,
P < 0.05), and Pi showed a trend to
increase in the leg muscle (2.8 ± 0.7 to 3.8 ± 0.3 mmHg, P = 0.08). These data
demonstrate that TER alb is
associated with PV regulation and that local transcapillary forces
in the leg muscle may favor retention of albumin in the vascular space
after exercise.
capillary filtration coefficient; Evans blue dye; interstitial
fluid colloid osmotic pressure; interstitial fluid hydrostatic
pressure; plasma volume
0161-7567/97 $5.00
Copyright © 1997 the American Physiological Society</description><identifier>ISSN: 8750-7587</identifier><identifier>EISSN: 1522-1601</identifier><identifier>DOI: 10.1152/jappl.1997.83.2.407</identifier><identifier>PMID: 9262434</identifier><identifier>CODEN: JAPHEV</identifier><language>eng</language><publisher>Bethesda, MD: Am Physiological Soc</publisher><subject>Adult ; Biological and medical sciences ; Capillaries - metabolism ; Capillary Permeability ; Colloids - metabolism ; Exercise ; Extracellular Space - metabolism ; Female ; Fundamental and applied biological sciences. Psychology ; Humans ; Hydrostatic Pressure ; Hyperemia - metabolism ; Male ; Microcirculation ; Muscle, Skeletal - blood supply ; Osmotic Pressure ; Plasma Volume ; Serum Albumin - metabolism ; Skin - blood supply ; Space life sciences ; Vertebrates: body movement. Posture. Locomotion. Flight. Swimming. Physical exercise. Rest. Sports</subject><ispartof>Journal of applied physiology (1985), 1997-08, Vol.83 (2), p.407-413</ispartof><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c502t-e7e36f81d6414434dd25879560bc4a96986b8fd37ead0b94752a7516521a323e3</citedby><cites>FETCH-LOGICAL-c502t-e7e36f81d6414434dd25879560bc4a96986b8fd37ead0b94752a7516521a323e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2807415$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9262434$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Haskell, Andrew</creatorcontrib><creatorcontrib>Nadel, Ethan R</creatorcontrib><creatorcontrib>Stachenfeld, Nina S</creatorcontrib><creatorcontrib>Nagashima, Kei</creatorcontrib><creatorcontrib>Mack, Gary W</creatorcontrib><title>Transcapillary escape rate of albumin in humans during exercise-induced hypervolemia</title><title>Journal of applied physiology (1985)</title><addtitle>J Appl Physiol (1985)</addtitle><description>Andrew
Haskell,
Ethan R.
Nadel,
Nina S.
Stachenfeld,
Kei
Nagashima, and
Gary W.
Mack
The John B. Pierce Laboratory and Departments of
Epidemiology and Public Health and of Cellular and Molecular
Physiology, Yale University School of Medicine, New Haven, Connecticut
06519
Received 16 December 1996; accepted in final form 2 April 1997.
Haskell, Andrew, Ethan R. Nadel, Nina S. Stachenfeld, Kei
Nagashima, and Gary W. Mack. Transcapillary escape rate of albumin
in humans during exercise-induced hypervolemia. J. Appl. Physiol. 83(2): 407-413, 1997. To test the
hypotheses that plasma volume (PV) expansion 24 h after intense
exercise is associated with reduced transcapillary escape rate of
albumin (TER alb ) and that local
changes in transcapillary forces in the previously active tissues favor
retention of protein in the vascular space, we measured PV,
TER alb , plasma colloid osmotic
pressure (COP p ), interstitial
fluid hydrostatic pressure (Pi), and colloid osmotic pressure in leg
muscle and skin and capillary filtration coefficient (CFC) in the arm
and leg in seven men and women before and 24 h after intense upright
cycle ergometer exercise. Exercise expanded PV by 6.4% at 24 h (43.9 ± 0.8 to 46.8 ± 1.2 ml/kg, P < 0.05) and decreased total protein concentration (6.5 ± 0.1 to
6.3 ± 0.1 g/dl, P < 0.05) and
COP p (26.1 ± 0.8 to 24.3 ± 0.9 mmHg, P < 0.05), although plasma
albumin concentration was unchanged. TER alb tended to decline (8.4 ± 0.5 to 6.5 ± 0.7%/h, P = 0.11) and was correlated with the increase in PV
( r = 0.69,
P < 0.05). CFC increased in the leg
(3.2 ± 0.2 to 4.3 ± 0.5 µl · 100 g 1 · min 1 · mmHg 1 ,
P < 0.05), and Pi showed a trend to
increase in the leg muscle (2.8 ± 0.7 to 3.8 ± 0.3 mmHg, P = 0.08). These data
demonstrate that TER alb is
associated with PV regulation and that local transcapillary forces
in the leg muscle may favor retention of albumin in the vascular space
after exercise.
capillary filtration coefficient; Evans blue dye; interstitial
fluid colloid osmotic pressure; interstitial fluid hydrostatic
pressure; plasma volume
0161-7567/97 $5.00
Copyright © 1997 the American Physiological Society</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Capillaries - metabolism</subject><subject>Capillary Permeability</subject><subject>Colloids - metabolism</subject><subject>Exercise</subject><subject>Extracellular Space - metabolism</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Hydrostatic Pressure</subject><subject>Hyperemia - metabolism</subject><subject>Male</subject><subject>Microcirculation</subject><subject>Muscle, Skeletal - blood supply</subject><subject>Osmotic Pressure</subject><subject>Plasma Volume</subject><subject>Serum Albumin - metabolism</subject><subject>Skin - blood supply</subject><subject>Space life sciences</subject><subject>Vertebrates: body movement. Posture. Locomotion. Flight. Swimming. Physical exercise. Rest. Sports</subject><issn>8750-7587</issn><issn>1522-1601</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><recordid>eNqFkEtv1DAUhS0EKkPhFyCkLBCskvrtZIkqCkiVupmuLSe-mbhyHtgT6Px77tChXaFKlmzpnnPP8UfIe0YrxhS_uHPLEivWNKaqRcUrSc0LssEJL5mm7CXZ1EbR0qjavCZvcr6jlEmp2Bk5a7jmUsgN2W6Tm3LnlhCjS4cCjm8okttDMfeFi-06hqnAM6wjKgu_pjDtCriH1IUMZZj82oEvhsMC6dccYQzuLXnVu5jh3ek-J7dXX7eX38vrm28_Lr9cl52ifF-CAaH7mnktsZeQ3nOs2ihN2066Rje1buveCwPO07aRRnFnFNOKMye4AHFOPj3sXdL8c4W8t2PIHeBPJpjXbE3DOa1x9XNCbiQzkmsUigdhl-acE_R2SWFEMJZRe4Ru_0K3R-i2FpZbhI6uD6f1azuCf_ScKOP842nuEG_sETmye5TxmmK-egofwm74HRLYZTjkMMd5d7BXa4xbuN8fC_wLtovv0fX5_y4UP9X8AxmzrBM</recordid><startdate>19970801</startdate><enddate>19970801</enddate><creator>Haskell, Andrew</creator><creator>Nadel, Ethan R</creator><creator>Stachenfeld, Nina S</creator><creator>Nagashima, Kei</creator><creator>Mack, Gary W</creator><general>Am Physiological Soc</general><general>American Physiological Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>H8D</scope><scope>L7M</scope><scope>7X8</scope></search><sort><creationdate>19970801</creationdate><title>Transcapillary escape rate of albumin in humans during exercise-induced hypervolemia</title><author>Haskell, Andrew ; Nadel, Ethan R ; Stachenfeld, Nina S ; Nagashima, Kei ; Mack, Gary W</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c502t-e7e36f81d6414434dd25879560bc4a96986b8fd37ead0b94752a7516521a323e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Capillaries - metabolism</topic><topic>Capillary Permeability</topic><topic>Colloids - metabolism</topic><topic>Exercise</topic><topic>Extracellular Space - metabolism</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Hydrostatic Pressure</topic><topic>Hyperemia - metabolism</topic><topic>Male</topic><topic>Microcirculation</topic><topic>Muscle, Skeletal - blood supply</topic><topic>Osmotic Pressure</topic><topic>Plasma Volume</topic><topic>Serum Albumin - metabolism</topic><topic>Skin - blood supply</topic><topic>Space life sciences</topic><topic>Vertebrates: body movement. Posture. Locomotion. Flight. Swimming. Physical exercise. Rest. Sports</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Haskell, Andrew</creatorcontrib><creatorcontrib>Nadel, Ethan R</creatorcontrib><creatorcontrib>Stachenfeld, Nina S</creatorcontrib><creatorcontrib>Nagashima, Kei</creatorcontrib><creatorcontrib>Mack, Gary W</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Aerospace Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of applied physiology (1985)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Haskell, Andrew</au><au>Nadel, Ethan R</au><au>Stachenfeld, Nina S</au><au>Nagashima, Kei</au><au>Mack, Gary W</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Transcapillary escape rate of albumin in humans during exercise-induced hypervolemia</atitle><jtitle>Journal of applied physiology (1985)</jtitle><addtitle>J Appl Physiol (1985)</addtitle><date>1997-08-01</date><risdate>1997</risdate><volume>83</volume><issue>2</issue><spage>407</spage><epage>413</epage><pages>407-413</pages><issn>8750-7587</issn><eissn>1522-1601</eissn><coden>JAPHEV</coden><abstract>Andrew
Haskell,
Ethan R.
Nadel,
Nina S.
Stachenfeld,
Kei
Nagashima, and
Gary W.
Mack
The John B. Pierce Laboratory and Departments of
Epidemiology and Public Health and of Cellular and Molecular
Physiology, Yale University School of Medicine, New Haven, Connecticut
06519
Received 16 December 1996; accepted in final form 2 April 1997.
Haskell, Andrew, Ethan R. Nadel, Nina S. Stachenfeld, Kei
Nagashima, and Gary W. Mack. Transcapillary escape rate of albumin
in humans during exercise-induced hypervolemia. J. Appl. Physiol. 83(2): 407-413, 1997. To test the
hypotheses that plasma volume (PV) expansion 24 h after intense
exercise is associated with reduced transcapillary escape rate of
albumin (TER alb ) and that local
changes in transcapillary forces in the previously active tissues favor
retention of protein in the vascular space, we measured PV,
TER alb , plasma colloid osmotic
pressure (COP p ), interstitial
fluid hydrostatic pressure (Pi), and colloid osmotic pressure in leg
muscle and skin and capillary filtration coefficient (CFC) in the arm
and leg in seven men and women before and 24 h after intense upright
cycle ergometer exercise. Exercise expanded PV by 6.4% at 24 h (43.9 ± 0.8 to 46.8 ± 1.2 ml/kg, P < 0.05) and decreased total protein concentration (6.5 ± 0.1 to
6.3 ± 0.1 g/dl, P < 0.05) and
COP p (26.1 ± 0.8 to 24.3 ± 0.9 mmHg, P < 0.05), although plasma
albumin concentration was unchanged. TER alb tended to decline (8.4 ± 0.5 to 6.5 ± 0.7%/h, P = 0.11) and was correlated with the increase in PV
( r = 0.69,
P < 0.05). CFC increased in the leg
(3.2 ± 0.2 to 4.3 ± 0.5 µl · 100 g 1 · min 1 · mmHg 1 ,
P < 0.05), and Pi showed a trend to
increase in the leg muscle (2.8 ± 0.7 to 3.8 ± 0.3 mmHg, P = 0.08). These data
demonstrate that TER alb is
associated with PV regulation and that local transcapillary forces
in the leg muscle may favor retention of albumin in the vascular space
after exercise.
capillary filtration coefficient; Evans blue dye; interstitial
fluid colloid osmotic pressure; interstitial fluid hydrostatic
pressure; plasma volume
0161-7567/97 $5.00
Copyright © 1997 the American Physiological Society</abstract><cop>Bethesda, MD</cop><pub>Am Physiological Soc</pub><pmid>9262434</pmid><doi>10.1152/jappl.1997.83.2.407</doi><tpages>7</tpages></addata></record> |
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| ispartof | Journal of applied physiology (1985), 1997-08, Vol.83 (2), p.407-413 |
| issn | 8750-7587 1522-1601 |
| language | eng |
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| source | American Physiological Society Free |
| subjects | Adult Biological and medical sciences Capillaries - metabolism Capillary Permeability Colloids - metabolism Exercise Extracellular Space - metabolism Female Fundamental and applied biological sciences. Psychology Humans Hydrostatic Pressure Hyperemia - metabolism Male Microcirculation Muscle, Skeletal - blood supply Osmotic Pressure Plasma Volume Serum Albumin - metabolism Skin - blood supply Space life sciences Vertebrates: body movement. Posture. Locomotion. Flight. Swimming. Physical exercise. Rest. Sports |
| title | Transcapillary escape rate of albumin in humans during exercise-induced hypervolemia |
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