Safe peripheral blood stem cell collection in patients less than 10 kg: A single‐center review

Introduction Peripheral blood stem cell collection (PBSCC) is well‐documented in adults and pediatric patients with larger total blood volume (TBV). However, very little data are available for the successful PBSCC of pediatric patients weighing less than 10 kg. Here, we highlight our institutional a...

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Bibliographic Details
Published in:Journal of clinical apheresis 2023-08, Vol.38 (4), p.390-395
Main Authors: Pasko, Bryce E., DomBourian, Melkon, Helander, Louise, Sanders, Mary, Annen, Kyle
Format: Article
Language:English
Subjects:
Adult
Antigens, CD34
Blood Volume
Bone Marrow Transplantation
cellular therapy
Child
Hematopoietic Stem Cell Mobilization
Humans
low weight
neonatal
pediatric
peripheral blood stem cell collection
Peripheral Blood Stem Cells
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Summary:Introduction Peripheral blood stem cell collection (PBSCC) is well‐documented in adults and pediatric patients with larger total blood volume (TBV). However, very little data are available for the successful PBSCC of pediatric patients weighing less than 10 kg. Here, we highlight our institutional approach to PBSCC in this smaller‐sized patient population. Methods Our protocol, including blood prime, was reviewed for PBSCC for bone marrow transplantation (BMT) in 18 children weighing 4.5‐9.9 kg who safely underwent 37 PBSCC procedures at a single institution, Children's Hospital Colorado, between September 2016 and February 2022. Results We attained the individualized collection goals in all 18 patients with an average yield of 17.03 million CD34+ cells/kg of patient body weight (range: 0.84‐67.45 million/kg). The average collection efficiency of the procedures was 41.5% (range: 23.0%‐71.5%). We performed all 37 procedures safely and without complication. The estimated average TBV was 587 mL (range: 351‐765 mL), the average blood volume processed was 596 mL (range: 351‐756 mL), and the average TBVs processed was 2.5 (range: 1‐4). Conclusion PBSCC in patients ranging from 4.5 to 9.9 kg is safe and effective for collecting peripheral blood stem cells for BMT.
ISSN:0733-2459
1098-1101
DOI:10.1002/jca.22035