Effect of Human Papillomavirus Subtype on the Rate of Positive Surgical Margin After Cervical Conization

Objective. Human papillomavirus (HPV) infection is a risk factor for cervical carcinoma. Over 100 types of HPV have been identified. The excisional procedures are recommended for women with high-grade cervical intraepithelial neoplasia. Surgical margin status is an important predictor of the risk of...

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Bibliographic Details
Published in:International journal of surgical pathology 2023-02, Vol.31 (1), p.20-25
Main Authors: Purut, Yunus Emre, Giray, Burak, Akis, Serkan, Peker, Esra Keles, Babayeva, Gulchin, Kabaca, Canan, Api, Murat
Format: Article
Language:English
Subjects:
Cervical cancer
Conization
Female
Human papillomavirus
Human papillomavirus 16 - genetics
Human papillomavirus 18
Human Papillomavirus Viruses
Humans
Margins of Excision
Neoplasm Recurrence, Local - pathology
Papillomaviridae
Papillomavirus Infections - complications
Papillomavirus Infections - surgery
Pregnancy
Retrospective Studies
Uterine Cervical Neoplasms - pathology
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Summary:Objective. Human papillomavirus (HPV) infection is a risk factor for cervical carcinoma. Over 100 types of HPV have been identified. The excisional procedures are recommended for women with high-grade cervical intraepithelial neoplasia. Surgical margin status is an important predictor of the risk of relapse. The aim of the current study was to evaluate whether HPV genotype is a predictive factor of positive surgical margin after cervical cone excision. Materials and Methods. The records of 448 HPV-infected patients who underwent loop electrosurgical excision or cold knife conization at a tertiary gynecological cancer center were retrospectively reviewed. The patients were divided into 6 groups according to HPV positivity: HPV 16 only, HPV 18 only, HPV 16/18, other high-risk HPV (hrHPV), HPV 16/hrHPV, and HPV 18/hrHPV. Results. There was no significant difference between the HPV groups in terms of age, parity, menopausal status, endocervical canal involvement, conization method, and the rates of positive margin (P = .15, P = .49, P = .07, P = .20, P = .24, P = .39, respectively). Conclusion. The results show that HPV subtypes might not be associated with endocervical canal involvement and the rates of positive margin. In addition, margin status was not related to the conization method and the number of excised cervical tissue.
ISSN:1066-8969
1940-2465
DOI:10.1177/10668969221143460