Outcomes of liver resection for huge hepatocellular carcinoma exceeding 10 cm in size: A single center experience

To evaluate our experience of resection for huge hepatocellular carcinoma (HCC) (exceeding 10 cm in diameter). We reviewed the patients’ data who underwent liver resection for huge HCC between 2010 and 2019. We divided them into two groups according to liver resection extent (minor/major). 40 patien...

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Bibliographic Details
Published in:The American journal of surgery 2023-06, Vol.225 (6), p.1013-1021
Main Authors: Elhanafy, Ehab, Aboelinin, Mohamed, Said, Rami, Elmahdy, Yousef, Aboelenin, Ahmed, Fouad, Amgad, Abdelwahab, Mohamed, Shehta, Ahmed
Format: Article
Language:English
Subjects:
Abdomen
Ablation
Carcinoma, Hepatocellular
Complications
Endoscopy
Hepatectomy - methods
Hepatocellular carcinoma
Humans
Laboratories
Large tumor
Liver
Liver cancer
Liver Neoplasms
Liver resection
Mortality
Patients
Retrospective Studies
Statistical analysis
Surgery
Survival
Survival analysis
Treatment Outcome
Tumors
Ultrasonic imaging
Viral infections
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Summary:To evaluate our experience of resection for huge hepatocellular carcinoma (HCC) (exceeding 10 cm in diameter). We reviewed the patients’ data who underwent liver resection for huge HCC between 2010 and 2019. We divided them into two groups according to liver resection extent (minor/major). 40 patients were included. Minor Group included 19 patients (47.5%), and Major Group included 21 patients (52.5%). Longer operation time, hospital stay, and more severe complications were found in Major Group. The 1-, 3-, and 5-years OS rates were 76.6%, 39.5%, and 39.5%, respectively. The 1-, 3-, and 5-year DFS rates were 65.6%, 40%, and 0%, respectively. There were no significant differences between the two groups regarding OS (p = 0.598) and DFS (p = 0.564). Liver resection for huge HCC is associated with average morbidities and mortality. Proper selection, adequate techniques and standardized care can provide favorable patients’ survival. •HCCs may be diagnosed at a more locally advanced status and with huge sizes (exceeding 10 cm in diameter).•Therapeutic modalities for patients with huge HCCs (exceeding 10 cm in diameter) are limited.•Liver resection for HCCs exceeding 10 cm in size is associated with acceptable perioperative morbidities and mortality.•Liver resection is associated with acceptable progression free survival but worser overall survival.•Proper case selection, adequate techniques and standardized care can provide favorable patients' survival.
ISSN:0002-9610
1879-1883
DOI:10.1016/j.amjsurg.2022.12.005