Static magnetic field blocked alprazolam-induced behavior of Wistar rats in the elevated plus-maze test

•Exposure to magnetic fields did not change the natural behavior in the EPM.•Low magnetic power possibly interacts with the drug mechanisms.•The static magnetic field blocked the alprazolam-induced behavior in the EPM test. Studies have shown that psychotropic drugs change rat behavior in the elevat...

Full description

Saved in:
Bibliographic Details
Published in:Neuroscience letters 2023-01, Vol.794, p.137013-137013, Article 137013
Main Authors: Brito, Raquel Cardoso, Olivato, Thairyne, Kitabatake, Takae Tamy, Zhang, Kelly, de Oliveira Guirro, Elaine Caldeira, de Araujo, João Eduardo
Format: Article
Language:English
Subjects:
Alprazolam
Alprazolam - pharmacology
Animals
Anti-Anxiety Agents - pharmacology
Anxiety
Anxiolytic-like behavior
Behavior, Animal
Elevated Plus Maze Test
Magnetic Fields
Male
Maze Learning
Rats
Rats, Wistar
Static magnetic field
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:•Exposure to magnetic fields did not change the natural behavior in the EPM.•Low magnetic power possibly interacts with the drug mechanisms.•The static magnetic field blocked the alprazolam-induced behavior in the EPM test. Studies have shown that psychotropic drugs change rat behavior in the elevated plus-maze test (EPM). This study investigated whether static magnetic fields could alter alprazolam-induced rat behavior in the EPM. 66 male Wistar rats (270–300 g weight) were assigned to one of the following groups: Sham Magnetic + Saline (SMS), North Pole + Saline (NPS), South Pole + Saline (SPS), Sham magnetic + alprazolam (SMA), NP + alprazolam (NPA), and SP + alprazolam (SPA). After five days of static magnetic stimulation (3200 Gauss), they received alprazolam or saline (1 mg/kg), and their behavior was evaluated. Two-way ANOVA and Holm-Sidak post-hock were used, with a significant P value of
ISSN:0304-3940
1872-7972
DOI:10.1016/j.neulet.2022.137013