Computational assessment of growth of connective tissues around textured hip stem subjected to daily activities after THA

• Published in: Medical & biological engineering & computing 2023-02, Vol.61 (2), p.525-540
• Main Authors: Ghosh, Rajdeep, Hazra, Ankan, Chanda, Souptick, Chakraborty, Debabrata
• Format: Article
• Language: English
• Subjects: Algorithms; Arthroplasty, Replacement, Hip - methods; Biomedical and Life Sciences; Biomedical Engineering and Bioengineering; Biomedical materials; Biomedicine; Bone growth; Bone implants; Bone-implant interfaces; Computer Applications; Connective Tissue; Connective tissues; Differentiation (biology); Femoral components; Femur; Femur - surgery; Finite element method; Hip; Hip Prosthesis; Human Physiology; Imaging; Interface stability; Original Article; Orthopaedic implants; Ossification; Phenotypes; Prosthesis Design; Radiology; Rehabilitation; Spatial distribution; Temporal distribution; Tissues; Transplants & implants; Walking
• ISSN: 0140-0118; 1741-0444
• DOI: 10.1007/s11517-022-02729-3

Longer-term stability of uncemented femoral stem depends on ossification at bone-implant interface. Although attempts have been made to assess the amount of bone growth using finite element (FE) analysis in combination with a mechanoregulatory algorithm, there has been little research on tissue differentiation patterns on hip stems with proximal macro-textures. The primary goal of this investigation is to qualitatively compare the formation of connective tissues around a femoral implant with/without macro-textures on its proximal surfaces. This study also predicts formation of different tissue phenotypes and their spatio-temporal distribution around a macro-textured femoral stem under routine activities. Results from the study show that non-textured implants (80 to 94%) encourage fibroplasia compared to that in textured implants (71 to 85.38%) under similar routine activity, which might trigger aseptic loosening of implant. Formation of bone was more on medio-lateral sides and towards proximal regions of Gruen zones 2 and 6, which was found to be in line with clinical observations. Fibroplasia was higher under stair climbing (85 to 91%) compared to that under normal walking (71 to 85.38%). This study suggests that stair climbing, although falls under recommended activity, might be detrimental to patient compared to normal walking in the initial rehabilitation period. Graphical abstract