Potential of HMGB‐inhibitory oligodeoxynucleotide ISM ODN to neutrophil recruitment in mouse model of hepatitis

High‐mobility group box 1 (HMGB1) is a nucleotide‐binding chromatin protein that has also been characterized as a prototypical damage‐associate molecular pattern. It triggers inflammatory responses upon release from damaged or dying cells. In fact, HMGB1 has been linked to the induction of many infl...

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Bibliographic Details
Published in:Genes to cells : devoted to molecular & cellular mechanisms 2023-03, Vol.28 (3), p.202-210
Main Authors: Inoue, Asuka, Chiba, Shiho, Eto, Shotaro, Taniguchi, Tadatsugu, Yanai, Hideyuki
Format: Article
Language:English
Subjects:
Animal models
Animals
Cell activation
Chromatin
concanavalin A
Disease Models, Animal
Hepatitis
HMGB
HMGB1 protein
HMGB1 Protein - metabolism
Inflammatory diseases
ISM ODN
Leukocytes (neutrophilic)
Mice
neutrophil
Neutrophil Infiltration
Oligodeoxyribonucleotides - pharmacology
sepsis
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Summary:High‐mobility group box 1 (HMGB1) is a nucleotide‐binding chromatin protein that has also been characterized as a prototypical damage‐associate molecular pattern. It triggers inflammatory responses upon release from damaged or dying cells. In fact, HMGB1 has been linked to the induction of many inflammatory diseases through immune cell activation including neutrophil recruitment. In this study, we examined the impact of HMGB1‐binding inhibitory oligodeoxynucleotide (ISM ODN) on the development of hepatitis using a murine model of the disease. Our results indicate that ISM ODN effectively suppresses pathological features of hepatitis, including neutrophil accumulation. This study therefore may offer clinical insight into the treatment of hepatitis and possibly other inflammatory diseases. HMGB1 is a nucleotide‐binding chromatin protein that has also been characterized as a prototypical damage‐associate molecular pattern. In this study, we examined the impact of HMGB1‐binding inhibitory oligodeoxynucleotide (ISM ODN) on development of hepatitis using murine model of the disease. Our results indicate that ISM ODN effectively suppresses pathological features of hepatitis, including neutrophil accumulation.
ISSN:1356-9597
1365-2443
DOI:10.1111/gtc.13002