Human gut microbiota stratified by (+)-catechin metabolism dynamics reveals colon region-dependent metabolic profile

•Colon region-dependent microbiota composition and metabolic profiles.•Converter-dependent microbial composition and metabolism of (+)-catechin.•Two catechin-metabolizing bacteria were distinguished between converters and colon regions.•Long-term (+)-catechin supplementation enriched catechin-metabo...

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Bibliographic Details
Published in:Food chemistry 2023-05, Vol.408, p.135203-135203, Article 135203
Main Authors: Li, Qiqiong, Stautemas, Jan, Omondi Onyango, Stanley, De Mey, Marjan, Duchi, Dries, Tuenter, Emmy, Hermans, Nina, Calders, Patrick, Van de Wiele, Tom
Format: Article
Language:English
Subjects:
(+)-Catechin
Bacteria - genetics
Bacteria - metabolism
Biotransformation
Catechin - metabolism
Catechin-metabolizing bacteria
colon
Colon - microbiology
Eggerthella
Flavonifractor
food chemistry
Gastrointestinal Microbiome
Gut microbiota
Humans
intestinal microorganisms
metabolism
metabolites
Metabolome
Microbiota
M−SHIME
placebos
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Summary:•Colon region-dependent microbiota composition and metabolic profiles.•Converter-dependent microbial composition and metabolism of (+)-catechin.•Two catechin-metabolizing bacteria were distinguished between converters and colon regions.•Long-term (+)-catechin supplementation enriched catechin-metabolizing bacteria. Catechins have proven to have several health benefits, yet a huge interindividual variability occurs. The metabolic potency of the colonic microbiota towards catechin is a key determinant of this variability. Microbiota from two donors – previously characterized as a fast and a slow converter– were incubated with (+)-catechin in vitro. The robustness of in vitro metabolic profiles was verified by well-fitted human trials. The colon region-dependent and donor-dependent patterns were reflected in both metabolic features and colonic microbiota composition. Upstream and downstream metabolites were mainly detected in the proximal and distal colons, respectively, and were considered important explanatory variables for microbiota clustering in the corresponding colon regions. Higher abundances of two catechin-metabolizing bacteria, Eggerthella and Flavonifractor were found in the distal colon compared to the proximal colon and in slow converter than fast converter. Additionally, these two bacteria were enriched in treatment samples compared to sham treatment samples.
ISSN:0308-8146
1873-7072
DOI:10.1016/j.foodchem.2022.135203