Effect of melatonin on oxidative stress indicators in animal models of fibrosis: A systematic review and meta-analysis

Imbalance of oxidative stress has been detected in a range of fibrotic diseases. Melatonin as an indoleamine hormone plays an important role in regulating the circadian rhythm of human, while in recent years, its antioxidant effect has also attracted increasing attention. This study aimed to perform...

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Published in:Free radical biology & medicine 2023-02, Vol.195, p.158-177
Main Authors: Li, Dan, Pan, Jun-Hua, Huang, Xiao-Fang, Liao, Yu-Qing, Ling, Yong-Jin, Luo, Jing-Ying
Format: Article
Language:English
Subjects:
Animals
Antioxidants - metabolism
Antioxidants - pharmacology
Catalase - metabolism
Fibrosis
Glutathione - metabolism
Glutathione Peroxidase - metabolism
Humans
Malondialdehyde - pharmacology
Melatonin
Melatonin - pharmacology
Meta-analysis
Models, Animal
Nitric Oxide - pharmacology
Oxidative Stress
Superoxide Dismutase - metabolism
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Summary:Imbalance of oxidative stress has been detected in a range of fibrotic diseases. Melatonin as an indoleamine hormone plays an important role in regulating the circadian rhythm of human, while in recent years, its antioxidant effect has also attracted increasing attention. This study aimed to perform a systematic review and meta-analysis to comprehensively evaluate the antioxidant effect of melatonin in animal models of fibrosis. The PubMed, Cochrane Library, EMBASE, Web of Science, China National Knowledge Infrastructure (CNKI), Wanfang database, China Science and Technology Journal Database (VIP), and SinoMed databases were searched from inception to March 1st, 2022 to retrieve eligible studies that evaluated the effect of melatonin supplementation on the levels of malondialdehyde (MDA), lipid peroxidation (LPO), nitric oxide (NO), superoxide dismutase (SOD), glutathione (GSH), glutathione peroxidase (GPx), and catalase (CAT) in animal models of fibrosis. A total of 64 studies were included in this meta-analysis. The results showed that melatonin supplementation significantly reduced the levels of oxidative indicators including MDA (P 
ISSN:0891-5849
1873-4596
DOI:10.1016/j.freeradbiomed.2022.12.094