Formulation development and evaluation of therapeutic contact lens loaded with ganciclovir

Purpose In the present investigation ganciclovir (GAN) loaded microparticles dispersed in hydrogel-based contact lenses were fabricated, characterized and evaluated for eye irritation. Methods GAN-Hydroxy Propyl Methyl Cellulose (HPMC) microparticles were prepared by solvent evaporation method and e...

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Bibliographic Details
Published in:International ophthalmology 2023-07, Vol.43 (7), p.2225-2236
Main Authors: Harsolekar, Mohit, Ansari, Mudassir, Supe, Shibani, Singh, Kavita
Format: Article
Language:English
Subjects:
Animals
Antiviral drugs
Cellulose
Chickens
Chorioallantoic membrane
Contact lenses
Contact Lenses, Hydrophilic
Drug delivery
Drug Delivery Systems - methods
Entrapment
Evaporation
Eye
Female
Free radical polymerization
Free radicals
Ganciclovir
Hydrogels
Irritation
Medicine
Medicine & Public Health
Membrane permeability
Methylcellulose
Microparticles
Morphology
Ophthalmology
Original Paper
Permeability
Photoinitiators
Polyhydroxyethyl methacrylate
Swelling
Transmittance
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Summary:Purpose In the present investigation ganciclovir (GAN) loaded microparticles dispersed in hydrogel-based contact lenses were fabricated, characterized and evaluated for eye irritation. Methods GAN-Hydroxy Propyl Methyl Cellulose (HPMC) microparticles were prepared by solvent evaporation method and evaluated for entrapment efficiency, drug content and drug release. The Polyhydroxyethylmethacrylate (pHEMA) contact lenses were synthesized by free radical polymerization reaction using crosslinkers like ethylene glycoldimethacrylate and photoinitiator such as IRGACURE 1173 ® , in UVB light, λ 365 nm. The GAN-HPMC microparticles when incorporated into the premonomer mixture and polymerized together give rise to a particle dispersion system in the hydrogel contact lenses. The contact lenses were studied for surface morphology, transmittance, swelling, drug release, Na + ion permeability and hens egg test chorioallantoic membrane assay (HETCAM). Results Hydrogel contact lens exhibited satisfactory surface morphology, transmittance, swelling, Na + ion permeability (3.72 × 106 mm 2 /min) and a release of 48 h suggesting a potential for prolonged ocular drug delivery. Furthermore, HETCAM exhibited no signs of ocular irritation. Conclusion The developed delivery platform is a promising alternative to conventional dosage forms like eye drops, suspensions and ointments due to its increase in the residence time attributed to its prolonged release profile.
ISSN:1573-2630
0165-5701
1573-2630
DOI:10.1007/s10792-022-02618-6