Low plasma 25-hydroxyvitamin D levels are associated with an increased risk of depressive symptoms in community-dwelling Japanese people aged between 40 and 74 years: The Murakami cohort study

Association between vitamin D levels and the occurrence of depression are not always consistent. The present cohort study aimed to determine this association in older adults, using a method for measuring vitamin D levels which is more accurate than those used in previous studies. Participants were 3...

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Published in:Journal of affective disorders 2023-03, Vol.325, p.48-54
Main Authors: Hinata, Aya, Kitamura, Kaori, Watanabe, Yumi, Kabasawa, Keiko, Saito, Toshiko, Takahashi, Akemi, Takachi, Ribeka, Kobayashi, Ryosaku, Oshiki, Rieko, Iki, Masayuki, Tsugane, Shoichiro, Sasaki, Ayako, Watanabe, Kei, Nakamura, Kazutoshi
Format: Article
Language:English
Subjects:
Adult
Aged
Cohort Studies
Cohort study
Depression
Depression - epidemiology
East Asian People
Female
Humans
Male
Mental health
Middle Aged
Risk factor
Sex difference
Vitamin D
Vitamin D - blood
Vitamin D Deficiency
Vitamins
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Summary:Association between vitamin D levels and the occurrence of depression are not always consistent. The present cohort study aimed to determine this association in older adults, using a method for measuring vitamin D levels which is more accurate than those used in previous studies. Participants were 3447 individuals aged 40–74 years without depressive symptoms at baseline who participated in the 5-year follow-up survey. The baseline investigation, including a self-administered questionnaire survey and blood collection, was conducted in 2011–2013. Plasma 25-hydroxyvitamin D (25[OH]D) levels were measured, and divided into overall quartiles summed up by sub-quartiles and stratified by age, sex, and season. The outcome was depressive symptoms determined by the CES-D (11-item, cut-off score of 6/7) 5 years later. Covariates were demographics, lifestyles, baseline CES-D score, and disease history. Mean plasma 25(OH)D levels were 58.0 nmol/L in men and 45.7 in women (P 
ISSN:0165-0327
1573-2517
DOI:10.1016/j.jad.2022.12.104