Development and application of an agent‐based model for the simulation of the extravasation process of circulating tumor cells

The primary cause for cancer‐related death is metastasis, and although this phenomenon is the hallmark of cancer, it remains poorly understood. Since studies on the underlying mechanisms are still demanding by experimental means prognostic tools based on computer models can be of great value, not on...

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Bibliographic Details
Published in:International journal for numerical methods in biomedical engineering 2023-04, Vol.39 (4), p.e3679-n/a
Main Authors: Schneider, Kay M., Giehl, Klaudia, Baeurle, Stephan A.
Format: Article
Language:English
Subjects:
Agent-based models
agent‐based model
Blood circulation
Blood Platelets - pathology
Cancer
circulating tumor cells
Computer applications
Computer Simulation
computer simulation of platelet‐assisted extravasation
Embedding
Extravasation
Humans
Mathematical models
Metastases
metastasis
Neoplastic Cells, Circulating - pathology
Platelets
Precision medicine
Prognosis
Simulation
Tumor cells
Tumors
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Summary:The primary cause for cancer‐related death is metastasis, and although this phenomenon is the hallmark of cancer, it remains poorly understood. Since studies on the underlying mechanisms are still demanding by experimental means prognostic tools based on computer models can be of great value, not only for elucidating metastasis formation but also for assessing the prospective benefits as well as risks of a therapy for patients with advanced cancer. Here, we present an agent‐based model (ABM), describing the complete process of platelet‐assisted extravasation of circulating tumor cells (CTCs) from the chemoattraction of blood platelets by the CTCs up to the embedding of the CTCs in the epithelial tissue by computational means. From the simulation results, we conclude that the ABM produces results in consistency with experimental observations, which opens new perspectives for the development of computer models for predicting the efficacity of drug‐based tumor therapies and assisting precision medicine approaches. A new agent‐based model for simulating the complete process of platelet‐assisted extravasation of circulating tumor cells (CTCs) is developed, consisting of four different simulation phases (Phase I‐IV). The process begins with the chemoattraction of blood platelets by the CTC and ends with the embedding of the CTC in the epithelial tissue. The simulation results of the model are shown to be in agreement with experimental observations.
ISSN:2040-7939
2040-7947
DOI:10.1002/cnm.3679