Donor-Derived Infection's Prevention and Control in Kidney Transplantation

• Published in: Transplantation proceedings 2023-01, Vol.55 (1), p.22-29
• Main Authors: Zhang, Xin, Shan, Hui, Zhang, Min, Yang, Hui, Gu, Li, Mi, Zixin, Wang, Xuezhu, Wang, Yaping, Tang, Ziren, Zhang, Xiaodong
• Format: Article
• Language: English
• Subjects: Bacterial Infections; Humans; Kidney; Kidney Transplantation - adverse effects; Mycoses; Prognosis; Retrospective Studies; Tissue Donors
• ISSN: 0041-1345; 1873-2623
• DOI: 10.1016/j.transproceed.2022.12.009

•Although the infection of the donor is common, the incidence of donor-derived infection (DDI) is relatively low.•The targeted and preventive application of antibiotics is the key to treatment.•Bacterial and fungi culture are necessary after transplantation.•Selecting the suitable receptors helps reduce the DDI. The study aimed to summarize the experience of donor selection and recipient therapy in the face of potential donor-derived infections and improve the quality of donor organ utilization, which would help reduce the risk of infection after recipient operation and decrease the risk of loss or even death of recipient kidney transplantation. In this study, 132 kidneys from 70 donors and their recipients who underwent surgery between July 2017 and January 2021 were studied to perform a retrospective analysis of their etiologic examination results and treatment process. In the 70 donors, only 25 had negative etiologic examination results, accounting for 35.71%. Among the 132 recipients, 31.82% had positive culture results, 3 (2.27%) experienced donor-derived infections, and one died. Although infection in the donor before the donation is quite common, the incidence of donor-derived infections is relatively low. The targeted and preventive application of adequate sensitive antibiotics in the whole course of therapy was the cornerstone for treating recipients at potential risk of potential donor-derived infection. The changes in infection indicators in the recipient should be closely monitored, which would guide medication adjustments timely. These measures could, to a great degree, ensure the prognosis of the recipient, in turn reducing the adverse events caused by donor-derived infections.