Hungry bone syndrome after parathyroid surgery

• Published in: Hemodialysis international 2023-04, Vol.27 (2), p.134-145
• Main Authors: Tai, Ya‐Ling, Shen, Hsin‐Yi, Nai, Wei‐Hsuan, Fu, Jen‐Fen, Wang, I‐Kuan, Huang, Chien‐Chang, Weng, Cheng‐Hao, Lee, Cheng‐Chia, Huang, Wen‐Hung, Yang, Huang‐Yu, Hsu, Ching‐Wei, Yen, Tzung‐Hai
• Format: Article
• Language: English
• Subjects: calcitriol; Calcium; cinacalcet; Humans; hungry bone syndrome; Hyperparathyroidism, Secondary - etiology; Hyperparathyroidism, Secondary - surgery; Hypocalcemia - diagnosis; Hypocalcemia - etiology; Hypocalcemia - surgery; Parathyroid Hormone; parathyroid hyperplasia; parathyroidectomy; Parathyroidectomy - adverse effects; Renal Dialysis - adverse effects; Retrospective Studies
• ISSN: 1492-7535; 1542-4758
• DOI: 10.1111/hdi.13067

Introduction Data on the incidence rates of hungry bone syndrome after parathyroidectomy in patients on dialysis are inconsistent, as the published rates vary from 15.8% to 92.9%. Methods Between 2009 and 2019, 120 hemodialysis patients underwent parathyroidectomy for secondary hyperparathyroidism at the Chang Gung Memorial Hospital. The patients were stratified into two groups based on the presence (n = 100) or absence (n = 20) of hungry bone syndrome after parathyroidectomy. Findings Subtotal parathyroidectomy was the most common surgery performed (76.7%), followed by total parathyroidectomy with autoimplantation (23.3%). Pathological examination revealed parathyroid hyperplasia. Hungry bone syndrome developed within 0.3 ± 0.3 months and lasted for 11.1 ± 14.7 months. After surgery, compared with patients without hungry bone syndrome, patients with hungry bone syndrome had lower levels of nadir corrected calcium (P