Oxidative stress triggers hyperdynamic circulation via central neural activation in portal hypertensive rats

Background Hyperdynamic circulation in portal hypertension (PHT) depends on central neural activation. However, the initiating mechanism that signals PHT to the central neural cardiovascular-regulatory centers remains unclear. We aimed to test the hypothesis that oxidative stress in the gut initiate...

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Published in:Hepatology international 2023-06, Vol.17 (3), p.689-697
Main Authors: Liu, Hongqun, Alhassan, Noura, Yoon, Ki Tae, Almutlaq, Lamees, Lee, Samuel S.
Format: Article
Language:English
Subjects:
Acetylcysteine
Animals
Blood circulation
Blood pressure
Cardiac output
Chemoreceptors
Colorectal Surgery
Heart
Hemodynamics
Hepatology
Hydrogen peroxide
Hydrogen Peroxide - pharmacology
Hypertension
Hypertension, Portal
Hypothalamus
Jejunum
Medicine
Medicine & Public Health
Nuclei
Original Article
Oxidation
Oxidative Stress
Paraventricular nucleus
Peroxidase
Peroxidase - metabolism
Peroxidase - pharmacology
Portal Vein
Rats
Rats, Sprague-Dawley
Surgery
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Summary:Background Hyperdynamic circulation in portal hypertension (PHT) depends on central neural activation. However, the initiating mechanism that signals PHT to the central neural cardiovascular-regulatory centers remains unclear. We aimed to test the hypothesis that oxidative stress in the gut initiates the signal that activates central cardiovascular nuclei in portal hypertensive rats. Methods Two groups of rats were used. One had portal hypertension produced by partial portal vein ligation, while controls underwent sham operation. Hemodynamics including portal pressure, cardiac output, mean arterial pressure (MAP) and peripheral vascular resistance were measured. Activation of central cardiovascular nuclei was determined by immunohistochemical Fos expression in the paraventricular nucleus (PVN) of the hypothalamus. Myeloperoxidase activity, an oxidative stress marker, was measured in the jejunum. Hydrogen peroxide, the antioxidant N -acetyl-cysteine (NAC) or saline controls were administered for 12–14 days by gavage or osmotic minipumps placed in the peritoneal cavity. Results Compared with controls, PHT rats showed increased cardiac output (54.2 ± 9.5 vs 33.6 ± 2.4 ml/min/100 g BW, p  
ISSN:1936-0533
1936-0541
DOI:10.1007/s12072-023-10481-5