Network intervention analysis of anxiety-related outcomes and processes of acceptance and commitment therapy (ACT) for anxious cancer survivors

• Published in: Behaviour research and therapy 2023-03, Vol.162, p.104266-104266, Article 104266
• Main Authors: Fishbein, Joel N., Haslbeck, Jonas, Arch, Joanna J.
• Format: Article
• Language: English
• Subjects: Acceptance and Commitment Therapy; Anxiety; Anxiety - psychology; Anxiety - therapy; Anxiety Disorders - therapy; Cancer; Cancer Survivors - psychology; Fear of recurrence; Humans; Mechanism; Mediation; Neoplasms - therapy; Network; Processes of change; Self-compassion; Survivorship; Treatment Outcome
• ISSN: 0005-7967; 1873-622X
• DOI: 10.1016/j.brat.2023.104266

Psychotherapies like Acceptance and Commitment Therapy (ACT) are thought to target multiple clinical outcomes by intervening on multiple mechanistic process variables. However, the standard mediation approach does not readily model the potentially complex associations among multiple processes and outcomes. The current study is one of the first to apply network intervention analysis to examine the putative change processes of a psychotherapy. Using data from a randomized trial of ACT versus minimally-enhanced usual care for anxious cancer survivors, we computed pre-to post-intervention (n = 113) residualized change scores on anxiety-related outcomes (general anxiety symptoms, cancer-related trauma symptoms, and fear of cancer recurrence) and putative processes of the intervention (experiential avoidance, self-compassion, and emotional approach coping). We estimated a network model with intervention condition and residualized change scores as nodes. Contrary to the expectation that intervention effects would pass indirectly to outcomes via processes, network analysis indicated that two anxiety-related outcomes of the trial may have acted as primary mechanisms of the intervention on other outcome and process variables. Network intervention analysis facilitated flexible evaluation of ACT's change processes, and offers a new way to test whether change occurs as theorized in psychotherapies. •Analyzed processes of acceptance and commitment therapy (ACT) via network analysis.•ACT directly targeted two cancer-specific, anxiety-related outcomes.•Indirect effects on theorized process variables via anxiety-related outcomes.•Indirect effects on general anxiety via cancer-specific anxiety-related outcomes.•Network intervention analysis may be useful for exploring therapeutic processes.