Hospital resource endowments and nosocomial infections: longitudinal evidence from the English National Health Service on Clostridioides difficile between 2011 and 2019

• Published in: The Journal of hospital infection 2023-04, Vol.134, p.129-137
• Main Authors: Stead, S., Vogt, L., Antons, D., Salge, T.O., Gecht, J., Klasen, M., Sopka, S.
• Format: Article
• Language: English
• Subjects: Clostridioides; Clostridioides difficile; Clostridioides difficle infection (CDI); Clostridium Infections - epidemiology; Clostridium Infections - prevention & control; Cross Infection - epidemiology; Cross Infection - prevention & control; Hospital acquired infections (HAIs); Hospitals, General; Humans; Longitudinal Studies; Nursing staff; Patient safety; State Medicine; Understaffing; Workload
• ISSN: 0195-6701; 1532-2939
• DOI: 10.1016/j.jhin.2023.01.014

To identify key factors associated with Clostridioides difficile infections (CDIs) in healthcare at the hospital organization level. Longitudinal study covering the period 2011–2019. Hospital reports were analysed to determine the number of CDIs and several hospital-related environmental factors: financial resources (i.e., cleaning expenditure), spatial resources (i.e., number of single rooms with a private bathroom), human resources (i.e., number of physicians and nursing staff) and cultural resources (i.e., error reporting climate). The relationships between the environmental factors and CDIs were analysed in a hybrid within- and between-hospital random-effect model. A total of 129 general hospital Trusts operating in the English National Health Service (NHS). All inpatients in 129 general hospital trusts of the NHS in the years 2011–2019, covering 120,629 cases of CDI. Annual number of CDIs per hospital trust. Single rooms were associated with fewer CDIs at the within-hospital level, but not at the between-hospital level. Similarly, more nursing staff was associated with fewer CDIs at the within-hospital level, but not at the between-hospital level. This effect was not observed for physician staffing. A different picture emerged for the protective effect of cultural resources, with a weakly significant effect of between-hospital differences, but no within-hospital effect. Financial resources were not associated with CDIs either between hospitals or within them over time. The present study identified hospital resources with a beneficial influence on CDI rates. Healthcare organizations can use this knowledge for active CDI prevention.