Recent Advances in Biomaterials‐Based Therapies for Alleviation and Regeneration of Traumatic Brain Injury

Traumatic brain injury (TBI), a major public health problem accompanied with numerous complications, usually leads to serve disability and huge financial burden. The adverse and unfavorable pathological environment triggers a series of secondary injuries, resulting in serious loss of nerve function...

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Bibliographic Details
Published in:Macromolecular bioscience 2023-05, Vol.23 (5), p.e2200577-n/a
Main Authors: Hu, Haijun, Chen, Xiping, Zhao, Kefei, Zheng, Weiwei, Gao, Changyou
Format: Article
Language:English
Subjects:
adaptive biomaterials
Biocompatible Materials - pharmacology
Biocompatible Materials - therapeutic use
Biomaterials
Biomedical materials
Brain
Brain Injuries, Traumatic - complications
Brain Injuries, Traumatic - therapy
Complications
Excitotoxicity
Head injuries
Humans
Inflammation
inflammation regulation
Injury prevention
Microenvironments
Nerve Regeneration
Nerves
Neurogenesis
Neurotrophic factors
Oxidative stress
Public health
Regeneration
Regeneration (physiology)
Stem Cells
Tissue engineering
tissue environment
tissue regeneration
Traumatic brain injury
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Summary:Traumatic brain injury (TBI), a major public health problem accompanied with numerous complications, usually leads to serve disability and huge financial burden. The adverse and unfavorable pathological environment triggers a series of secondary injuries, resulting in serious loss of nerve function and huge obstacle of endogenous nerve regeneration. With the advances in adaptive tissue regeneration biomaterials, regulation of detrimental microenvironment to reduce the secondary injury and to promote the neurogenesis becomes possible. The adaptive biomaterials could respond and regulate biochemical, cellular, and physiological events in the secondary injury, including excitotoxicity, oxidative stress, and neuroinflammation, to rebuild circumstances suitable for regeneration. In this review, the development of pathology after TBI is discussed, followed by the introduction of adaptive biomaterials based on various pathological characteristics. The adaptive biomaterials carried with neurotrophic factors and stem cells for TBI treatment are then summarized. Finally, the current drawbacks and future perspective of biomaterials for TBI treatment are suggested. Understanding the epidemiology and pathology of traumatic brain injury (TBI) helps in the design of biomaterials for TBI therapy, which can regulate biochemical stress, alleviate neuroinflammation and promote neural regeneration. Perspectives and future measures of biomaterials design for nerve regeneration are discussed to improve therapeutic outcomes.
ISSN:1616-5187
1616-5195
DOI:10.1002/mabi.202200577