Radical-mediated photoredox hydroarylation with thiosulfonate

Herein, we report a novel visible light-induced photocatalytic system that enables intramolecular hydroarylation of unactivated alkenes. Thiosulfonate compounds were found to be the key radical precursor that mediates the Minisci-type intramolecular cyclization reaction. Under the optimal reaction c...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2023-03, Vol.59 (19), p.2767-277
Main Authors: Wan, Xiaoyuan, Wang, Dahan, Huang, Huawen, Mao, Guo-Jiang, Deng, Guo-Jun
Format: Article
Language:English
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Summary:Herein, we report a novel visible light-induced photocatalytic system that enables intramolecular hydroarylation of unactivated alkenes. Thiosulfonate compounds were found to be the key radical precursor that mediates the Minisci-type intramolecular cyclization reaction. Under the optimal reaction conditions, a wide range of pyridyquinazolinone and pyrroloquinazolinone products were obtained in moderate to good yields. Radical-mediated photoredox hydroarylation reaction of unactivated alkenes using thiosulfonate compounds as key radical precursors to synthesize pyridyquinazolinone and pyrroloquinazolinone derivatives is described.
ISSN:1359-7345
1364-548X
DOI:10.1039/d2cc05948g