Pallidal Beta Activity Is Linked to Stimulation‐Induced Slowness in Dystonia

ABSTRACT Background Pallidal deep brain stimulation (DBS) effectively alleviates symptoms in dystonia patients, but may induce movement slowness as a side‐effect. In Parkinson's disease, hypokinetic symptoms have been associated with increased beta oscillations (13–30 Hz). We hypothesize that t...

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Bibliographic Details
Published in:Movement disorders 2023-05, Vol.38 (5), p.894-899
Main Authors: Lofredi, Roxanne, Scheller, Ute, Mindermann, Aurika, Feldmann, Lucia K., Krauss, Joachim K., Saryyeva, Assel, Schneider, Gerd‐Helge, Kühn, Andrea A.
Format: Article
Language:English
Subjects:
beta oscillations
bradykinesia
Deep brain stimulation
Dystonia
GPi
Movement disorders
Neurodegenerative diseases
Oscillations
Parkinson's disease
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Summary:ABSTRACT Background Pallidal deep brain stimulation (DBS) effectively alleviates symptoms in dystonia patients, but may induce movement slowness as a side‐effect. In Parkinson's disease, hypokinetic symptoms have been associated with increased beta oscillations (13–30 Hz). We hypothesize that this pattern is symptom‐specific, thus accompanying DBS‐induced slowness in dystonia. Methods In 6 dystonia patients, pallidal rest recordings with a sensing‐enabled DBS device were performed and tapping speed was assessed using marker‐less pose estimation over 5 time points following cessation of DBS. Results After cessation of pallidal stimulation, movement speed increased over time (P 
ISSN:0885-3185
1531-8257
DOI:10.1002/mds.29347