Lipid-based amphotericin B gel treatment eradicates vulvovaginal candidiasis in patients who failed to azole therapy

Vaginal yeast infection is one of the most common diseases caused by vulvovaginal candidiasis (VVC). Effective therapy for VVC is needed. A lipid-based amphotericin B gel 0.1% (LAB) was developed and evaluated for the treatment of VVC patients and those who failed to azole therapy. LAB was applied t...

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Published in:Archives of dermatological research 2023-09, Vol.315 (7), p.1939-1944
Main Authors: Sheikh, Saifuddin, Ahmad, Ateeq, Ali, Shoukath M., Paithankar, Mahesh, Patel, Ronak, Chuadhari, Shushil, Dave, Purvi M., Bhomia, Mamta V., Desai, Jagruti Y., Munshi, Atul, Shah, Meenakshi N., Desai, Kirankumar R., Dongre, Swati A., Walvekar, Shraddha A., Ahmad, Imran
Format: Article
Language:English
Subjects:
Amphotericin B
Antifungal agents
Candidiasis
Clinical trials
Dermatology
Medicine
Medicine & Public Health
Original Paper
Patients
Remission
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Summary:Vaginal yeast infection is one of the most common diseases caused by vulvovaginal candidiasis (VVC). Effective therapy for VVC is needed. A lipid-based amphotericin B gel 0.1% (LAB) was developed and evaluated for the treatment of VVC patients and those who failed to azole therapy. LAB was applied topically twice daily for 7 days to 64 moderate patients and 14 days to 55 severely infected VVC patients. Additionally, 66 patients who failed to azole therapy were treated twice daily with LAB for 14 days. A 91.5% clinical response and 93.16% mycological response was observed in VVC patients. The patients treated with LAB who failed to azole therapy showed a 75% clinical, 95.3% mycological response and 83% remission was observed. Overall, the LAB was found to be efficacious and safe for the treatment of VVC patients. Clinical Trial Registration All the trials were registered at Clinical Trial Registry of India (CTRI/2013/02/003378, CTRI/2014/02/004409).
ISSN:1432-069X
0340-3696
1432-069X
DOI:10.1007/s00403-023-02583-9