Prognostic Significance of Peak Workload-to-Weight Ratio by Cardiopulmonary Exercise Testing in Chronic Heart Failure

The prognostic impact of peak workload-to-weight ratio (PWR) during cardiopulmonary exercise testing (CPET) and its determinants in patients with chronic heart failure (CHF) are not well understood. Consecutive 514 patients with CHF referred for CPET at the Hokkaido University Hospital between 2013...

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Bibliographic Details
Published in:The American journal of cardiology 2023-04, Vol.193, p.37-43
Main Authors: Yasui, Yutaro, Nakamura, Kosuke, Omote, Kazunori, Ishizaka, Suguru, Takenaka, Sakae, Mizuguchi, Yoshifumi, Shimono, Yui, Kazui, Sho, Takahashi, Yuki, Saiin, Kohei, Naito, Seiichiro, Tada, Atsushi, Kobayashi, Yuta, Sato, Takuma, Kamiya, Kiwamu, Nagai, Toshiyuki, Anzai, Toshihisa
Format: Article
Language:English
Subjects:
Blood pressure
Body weight
Carbon dioxide
Cardiac arrhythmia
Cardiac catheterization
Chronic Disease
Confidence intervals
Congestive heart failure
Dyspnea
Ejection fraction
Exercise Test
Heart failure
Heart Failure - drug therapy
Heart rate
Hemodynamics
Hemoglobin
Hospitalization
Humans
Intubation
Mortality
Oxygen Consumption
Patients
Prognosis
Pulmonary arteries
Regression analysis
Statistical analysis
Workload
Workloads
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Summary:The prognostic impact of peak workload-to-weight ratio (PWR) during cardiopulmonary exercise testing (CPET) and its determinants in patients with chronic heart failure (CHF) are not well understood. Consecutive 514 patients with CHF referred for CPET at the Hokkaido University Hospital between 2013 and 2018 were identified. The primary outcome was a composite of hospitalization because of worsening heart failure and death. PWR was calculated as peak workload normalized to body weight (W/kg) by CPET. Patients with low PWR (cut-off median 1.38 [W/kg], n = 257) were older and more anemic than those with high PWR (n = 257). In CPET, patients with low PWR displayed reduced peak oxygen consumption and impaired ventilatory efficiency compared with those with high PWR, whereas the peak respiratory exchange ratio was not significantly different between the 2 groups. There were 89 patients with events over a median follow-up period of 3.3 (interquartile range 0.8 to 5.5) years. The incidence of composite events was significantly higher in patients with low PWR than in those with high PWR (log-rank p
ISSN:0002-9149
1879-1913
DOI:10.1016/j.amjcard.2023.01.052