Photo‐Responsive Hydrogel for Contactless Dressing Change to Attenuate Secondary Damage and Promote Diabetic Wound Healing

Dressing change is a significant and inevitable process during wound healing. Possible secondary damage caused through dressing removal may impose a great threat on wound recovery, thus resulting in healing delays and ultimately a higher cost of hospitalization. Hence, a non‐contact refreshable dres...

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Bibliographic Details
Published in:Advanced healthcare materials 2023-07, Vol.12 (17), p.e2202770-n/a
Main Authors: Li, Zi‐Yuan, Zhang, Xiao‐Jie, Gao, Yi‐Ming, Song, Yanyan, Sands, Mia X., Zhou, Shuang‐Bai, Li, Qing‐Feng, Zhang, Junji
Format: Article
Language:English
Subjects:
Animal models
Cell proliferation
chronic wounds
Controllability
Damage
Diabetes mellitus
dressing materials
Hydrogels
Inflammation
Light irradiation
photo‐responsiveness
Radiation
secondary damage
Synergistic effect
trauma reconstruction
Wound healing
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Summary:Dressing change is a significant and inevitable process during wound healing. Possible secondary damage caused through dressing removal may impose a great threat on wound recovery, thus resulting in healing delays and ultimately a higher cost of hospitalization. Hence, a non‐contact refreshable dressing with an ease of operation is of great desire, especially for chronic wounds where a long‐term and repeated dressing change would be performed. Herein, an all‐light‐operated hydrogel dressing that would achieve a fast and remote‐controllable dressing change (30 s for gelation/4 min for dissolution upon light irradiation) for chronic wounds is presented. In a diabetic murine model, substantially improved wound healing within 2–3 weeks is observed due to attenuated secondary damage during repeated dressing changes. Moreover, a promising facilitation of the healing processes of epithelialization, collagen deposition, cell proliferation, and inflammatory regulation is also detected, representing a synergistic effect of the photo‐responsive hydrogel dressing for therapeutic efficiency. An in situ on‐demand gelation/dissolution hydrogel dressing is developed for chronic wounds to reduce the secondary damage from repeated dressing changes. The hydrogel dressing enabled fast wound sealing within 30 s and on‐demand dissolution within 4 min, allowing fast and noninvasive dressing application and removal, as well as healing promotion.
ISSN:2192-2640
2192-2659
DOI:10.1002/adhm.202202770