Baseline metrics that may predict future myopia in young children

Purpose We used baseline data from the PICNIC longitudinal study to investigate structural, functional, behavioural and heritable metrics that may predict future myopia in young children. Methods Cycloplegic refractive error (M) and optical biometry were obtained in 97 young children with functional...

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Bibliographic Details
Published in:Ophthalmic & physiological optics 2023-05, Vol.43 (3), p.466-481
Main Authors: Vera‐Diaz, Fuensanta A., Jnawali, Ashutosh, Panorgias, Athanasios, Bex, Peter J., Kerber, Kristen L.
Format: Article
Language:English
Subjects:
Anterior chamber
Axl protein
Benchmarking
Child
Child, Preschool
Children
Classification
Cornea
Female
Humans
Longitudinal Studies
Myopia
Myopia - diagnosis
Refraction, Ocular
Refractive Errors
Regression analysis
Structure-function relationships
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Summary:Purpose We used baseline data from the PICNIC longitudinal study to investigate structural, functional, behavioural and heritable metrics that may predict future myopia in young children. Methods Cycloplegic refractive error (M) and optical biometry were obtained in 97 young children with functional emmetropia. Children were classified as high risk (HR) or low risk (LR) for myopia based on parental myopia and M. Other metrics included axial length (AXL), axial length/corneal radius (AXL/CR) and refractive centile curves. Results Based on the PICNIC criteria, 46 children (26 female) were classified as HR (M = +0.62 ± 0.44 D, AXL = 22.80 ± 0.64 mm) and 51 (27 female) as LR (M = +1.26 ± 0.44 D, AXL = 22.77 ± 0.77 mm). Based on centiles, 49 children were HR, with moderate agreement compared with the PICNIC classification (k = 0.65, p 
ISSN:0275-5408
1475-1313
DOI:10.1111/opo.13113