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Genetic predisposition to depression and inflammation impacts symptom burden and survival in patients with head and neck cancer: A longitudinal study
The primary purpose of this study was to investigate the contribution of genetic predispositions to depression and inflammation, as measured through polygenic risk scores, on symptom burden (physical and psychological) in patients with head and neck cancer in the immediate post-treatment period (i.e...
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| Published in: | Journal of affective disorders 2023-06, Vol.331, p.149-157 |
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| container_title | Journal of affective disorders |
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| creator | Henry, Melissa Harvey, Raphaële Chen, Lawrence M. Meaney, Michael Nguyen, Thi Thu Thao Kao, Han-Tin Rosberger, Zeev Frenkiel, Saul Hier, Michael Zeitouni, Anthony Kost, Karen Mlynarek, Alex Richardson, Keith Greenwood, Celia M.T. Melnychuk, David Gold, Phil Chartier, Gabrielle Black, Martin Mascarella, Marco MacDonald, Christina Sadeghi, Nader Sultanem, Khalil Shenouda, Georges Cury, Fabio O'Donnell, Kieran John |
| description | The primary purpose of this study was to investigate the contribution of genetic predispositions to depression and inflammation, as measured through polygenic risk scores, on symptom burden (physical and psychological) in patients with head and neck cancer in the immediate post-treatment period (i.e., at three months post-diagnosis), as well as on 3-, 6-, 12-, 24- and 36-month survival.
Prospective longitudinal study of 223 adults (72 % participation) newly diagnosed with a first occurrence of primary head and neck cancer, paired with genetic data (Illumina PsychArray), validated psychometric measures, Structured Clinical Interviews for DSM Disorders (SCID-I), and medical chart reviews.
Symptom burden at 3 months was predicted by (R2 adj. = 0.38, p |
| doi_str_mv | 10.1016/j.jad.2023.03.007 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2790052769</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0165032723003373</els_id><sourcerecordid>2790052769</sourcerecordid><originalsourceid>FETCH-LOGICAL-c396t-e53d8ccf99998134aab43e99fe97fbada087c3893bfc5e63c5d931cf95f609693</originalsourceid><addsrcrecordid>eNp9kdFOHCEUhknTpq7aB-iN4bI3s8KwA4O9MsaqiYk39ZowcKaynYERmDX7IL5v2V3tpeQkHOD7_4TzI_SdkiUllJ-vl2ttlzWp2ZKUIuITWtBGsKpuqPiMFoVpKsJqcYSOU1oTQrgU5Cs6Ylyu2hXnC_R6Ax6yM3iKYF2aQnLZBY9zwBbKXUq7k_YWO98Pehz1_tmNkzY54bQdpxxG3M3RwoFLc9y4jR6KAE-FBl-4F5ef8BNou0c8mL_YaG8gXuBLPAT_x-XZOl9UqTTbU_Sl10OCb2_7CXr8df376ra6f7i5u7q8rwyTPFfQMNsa08uyWspWWncrBlL2IEXfaatJKwxrJet60wBnprGS0cI3PSeSS3aCfhx8pxieZ0hZjS4ZGAbtIcxJ1UIS0tRij9IDamJIKUKvpuhGHbeKErVLQ61VSUPt0lCkFBFFc_ZmP3cj2P-K9_EX4OcBgPLJjYOokikDMyWKCCYrG9wH9v8As8-ehQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2790052769</pqid></control><display><type>article</type><title>Genetic predisposition to depression and inflammation impacts symptom burden and survival in patients with head and neck cancer: A longitudinal study</title><source>ScienceDirect Freedom Collection</source><creator>Henry, Melissa ; Harvey, Raphaële ; Chen, Lawrence M. ; Meaney, Michael ; Nguyen, Thi Thu Thao ; Kao, Han-Tin ; Rosberger, Zeev ; Frenkiel, Saul ; Hier, Michael ; Zeitouni, Anthony ; Kost, Karen ; Mlynarek, Alex ; Richardson, Keith ; Greenwood, Celia M.T. ; Melnychuk, David ; Gold, Phil ; Chartier, Gabrielle ; Black, Martin ; Mascarella, Marco ; MacDonald, Christina ; Sadeghi, Nader ; Sultanem, Khalil ; Shenouda, Georges ; Cury, Fabio ; O'Donnell, Kieran John</creator><creatorcontrib>Henry, Melissa ; Harvey, Raphaële ; Chen, Lawrence M. ; Meaney, Michael ; Nguyen, Thi Thu Thao ; Kao, Han-Tin ; Rosberger, Zeev ; Frenkiel, Saul ; Hier, Michael ; Zeitouni, Anthony ; Kost, Karen ; Mlynarek, Alex ; Richardson, Keith ; Greenwood, Celia M.T. ; Melnychuk, David ; Gold, Phil ; Chartier, Gabrielle ; Black, Martin ; Mascarella, Marco ; MacDonald, Christina ; Sadeghi, Nader ; Sultanem, Khalil ; Shenouda, Georges ; Cury, Fabio ; O'Donnell, Kieran John</creatorcontrib><description>The primary purpose of this study was to investigate the contribution of genetic predispositions to depression and inflammation, as measured through polygenic risk scores, on symptom burden (physical and psychological) in patients with head and neck cancer in the immediate post-treatment period (i.e., at three months post-diagnosis), as well as on 3-, 6-, 12-, 24- and 36-month survival.
Prospective longitudinal study of 223 adults (72 % participation) newly diagnosed with a first occurrence of primary head and neck cancer, paired with genetic data (Illumina PsychArray), validated psychometric measures, Structured Clinical Interviews for DSM Disorders (SCID-I), and medical chart reviews.
Symptom burden at 3 months was predicted by (R2 adj. = 0.38, p < 0.001): a baseline SCID-I Anxiety Disorder (b = 1.69, B = 0.23, 95%CI = 0.43–2.94; p = 0.009), baseline levels of HADS anxiety (b = 0.20, B = 0.29, 95%CI = 0.07–0.34; p = 0.003), the polygenic risk score (PRS) for depression (b = 0.66, B = 0.18, 95%CI = 0.003–1.32; p = 0.049), and cumulated dose of radiotherapy (b = 0.002, B = 0.46, 95%CI = 0.001–0.003; p < 0.001). When controlling for factors known to be associated with cancer survival, patients with a higher PRS associated with depression and inflammation, respectively, presented higher risk of death within 36 months (b = 1.75, Exp(B) = 5.75, 95%CI = 1.55–21.27, p = 0.009 and b = 0.14, Exp(B) = 1.15, 95%CI = 1.01–1.30, p = 0.03).
Our results outline three potential pathways of symptom burden in patients with head and neck cancer: a genetic predisposition towards depression; an initial anxiety disorder upon being diagnosed with cancer or high levels of anxiety upon diagnosis; and a dose-related response to radiotherapy. One may want to investigate early interventions in these areas to alleviate symptom burden in patients faced with a life-threatening disease, as well as consider targeting genetic predisposition towards depression and inflammation implicated in survival. The high prevalence of distress in patients with head and neck cancer is an opportunity to study genetic predispositions, which could potentially be broadly generalized to other cancers and diseases.
•Our results outline three pathways of symptom burden in head and neck cancer: a genetic predisposition towards depression; an initial anxiety disorder upon cancer diagnosis or high anxiety levels upon diagnosis; and a dose-related response to radiotherapy.•A genetic predisposition for depression significantly predicts 3-year survival in head and neck cancer.•One warrants investigating early interventions in these areas to alleviate symptom burden in patients faced with a life-threatening disease, as well as consider targeting genetic predisposition towards depression and inflammation implicated in survival.</description><identifier>ISSN: 0165-0327</identifier><identifier>EISSN: 1573-2517</identifier><identifier>DOI: 10.1016/j.jad.2023.03.007</identifier><identifier>PMID: 36948466</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Adult ; Anxiety - genetics ; Anxiety - psychology ; Cancer ; Depression ; Depression - diagnosis ; Depression - genetics ; Early detection ; Genetic Predisposition to Disease - genetics ; Genetics ; Head and neck cancer ; Head and Neck Neoplasms - genetics ; Humans ; Inflammation ; Inflammation - genetics ; Longitudinal Studies ; Oncology ; Polygenic risk score ; Prevention ; Prospective Studies ; Survival ; Symptom burden</subject><ispartof>Journal of affective disorders, 2023-06, Vol.331, p.149-157</ispartof><rights>2023</rights><rights>Published by Elsevier B.V.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c396t-e53d8ccf99998134aab43e99fe97fbada087c3893bfc5e63c5d931cf95f609693</citedby><cites>FETCH-LOGICAL-c396t-e53d8ccf99998134aab43e99fe97fbada087c3893bfc5e63c5d931cf95f609693</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36948466$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Henry, Melissa</creatorcontrib><creatorcontrib>Harvey, Raphaële</creatorcontrib><creatorcontrib>Chen, Lawrence M.</creatorcontrib><creatorcontrib>Meaney, Michael</creatorcontrib><creatorcontrib>Nguyen, Thi Thu Thao</creatorcontrib><creatorcontrib>Kao, Han-Tin</creatorcontrib><creatorcontrib>Rosberger, Zeev</creatorcontrib><creatorcontrib>Frenkiel, Saul</creatorcontrib><creatorcontrib>Hier, Michael</creatorcontrib><creatorcontrib>Zeitouni, Anthony</creatorcontrib><creatorcontrib>Kost, Karen</creatorcontrib><creatorcontrib>Mlynarek, Alex</creatorcontrib><creatorcontrib>Richardson, Keith</creatorcontrib><creatorcontrib>Greenwood, Celia M.T.</creatorcontrib><creatorcontrib>Melnychuk, David</creatorcontrib><creatorcontrib>Gold, Phil</creatorcontrib><creatorcontrib>Chartier, Gabrielle</creatorcontrib><creatorcontrib>Black, Martin</creatorcontrib><creatorcontrib>Mascarella, Marco</creatorcontrib><creatorcontrib>MacDonald, Christina</creatorcontrib><creatorcontrib>Sadeghi, Nader</creatorcontrib><creatorcontrib>Sultanem, Khalil</creatorcontrib><creatorcontrib>Shenouda, Georges</creatorcontrib><creatorcontrib>Cury, Fabio</creatorcontrib><creatorcontrib>O'Donnell, Kieran John</creatorcontrib><title>Genetic predisposition to depression and inflammation impacts symptom burden and survival in patients with head and neck cancer: A longitudinal study</title><title>Journal of affective disorders</title><addtitle>J Affect Disord</addtitle><description>The primary purpose of this study was to investigate the contribution of genetic predispositions to depression and inflammation, as measured through polygenic risk scores, on symptom burden (physical and psychological) in patients with head and neck cancer in the immediate post-treatment period (i.e., at three months post-diagnosis), as well as on 3-, 6-, 12-, 24- and 36-month survival.
Prospective longitudinal study of 223 adults (72 % participation) newly diagnosed with a first occurrence of primary head and neck cancer, paired with genetic data (Illumina PsychArray), validated psychometric measures, Structured Clinical Interviews for DSM Disorders (SCID-I), and medical chart reviews.
Symptom burden at 3 months was predicted by (R2 adj. = 0.38, p < 0.001): a baseline SCID-I Anxiety Disorder (b = 1.69, B = 0.23, 95%CI = 0.43–2.94; p = 0.009), baseline levels of HADS anxiety (b = 0.20, B = 0.29, 95%CI = 0.07–0.34; p = 0.003), the polygenic risk score (PRS) for depression (b = 0.66, B = 0.18, 95%CI = 0.003–1.32; p = 0.049), and cumulated dose of radiotherapy (b = 0.002, B = 0.46, 95%CI = 0.001–0.003; p < 0.001). When controlling for factors known to be associated with cancer survival, patients with a higher PRS associated with depression and inflammation, respectively, presented higher risk of death within 36 months (b = 1.75, Exp(B) = 5.75, 95%CI = 1.55–21.27, p = 0.009 and b = 0.14, Exp(B) = 1.15, 95%CI = 1.01–1.30, p = 0.03).
Our results outline three potential pathways of symptom burden in patients with head and neck cancer: a genetic predisposition towards depression; an initial anxiety disorder upon being diagnosed with cancer or high levels of anxiety upon diagnosis; and a dose-related response to radiotherapy. One may want to investigate early interventions in these areas to alleviate symptom burden in patients faced with a life-threatening disease, as well as consider targeting genetic predisposition towards depression and inflammation implicated in survival. The high prevalence of distress in patients with head and neck cancer is an opportunity to study genetic predispositions, which could potentially be broadly generalized to other cancers and diseases.
•Our results outline three pathways of symptom burden in head and neck cancer: a genetic predisposition towards depression; an initial anxiety disorder upon cancer diagnosis or high anxiety levels upon diagnosis; and a dose-related response to radiotherapy.•A genetic predisposition for depression significantly predicts 3-year survival in head and neck cancer.•One warrants investigating early interventions in these areas to alleviate symptom burden in patients faced with a life-threatening disease, as well as consider targeting genetic predisposition towards depression and inflammation implicated in survival.</description><subject>Adult</subject><subject>Anxiety - genetics</subject><subject>Anxiety - psychology</subject><subject>Cancer</subject><subject>Depression</subject><subject>Depression - diagnosis</subject><subject>Depression - genetics</subject><subject>Early detection</subject><subject>Genetic Predisposition to Disease - genetics</subject><subject>Genetics</subject><subject>Head and neck cancer</subject><subject>Head and Neck Neoplasms - genetics</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Inflammation - genetics</subject><subject>Longitudinal Studies</subject><subject>Oncology</subject><subject>Polygenic risk score</subject><subject>Prevention</subject><subject>Prospective Studies</subject><subject>Survival</subject><subject>Symptom burden</subject><issn>0165-0327</issn><issn>1573-2517</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNp9kdFOHCEUhknTpq7aB-iN4bI3s8KwA4O9MsaqiYk39ZowcKaynYERmDX7IL5v2V3tpeQkHOD7_4TzI_SdkiUllJ-vl2ttlzWp2ZKUIuITWtBGsKpuqPiMFoVpKsJqcYSOU1oTQrgU5Cs6Ylyu2hXnC_R6Ax6yM3iKYF2aQnLZBY9zwBbKXUq7k_YWO98Pehz1_tmNkzY54bQdpxxG3M3RwoFLc9y4jR6KAE-FBl-4F5ef8BNou0c8mL_YaG8gXuBLPAT_x-XZOl9UqTTbU_Sl10OCb2_7CXr8df376ra6f7i5u7q8rwyTPFfQMNsa08uyWspWWncrBlL2IEXfaatJKwxrJet60wBnprGS0cI3PSeSS3aCfhx8pxieZ0hZjS4ZGAbtIcxJ1UIS0tRij9IDamJIKUKvpuhGHbeKErVLQ61VSUPt0lCkFBFFc_ZmP3cj2P-K9_EX4OcBgPLJjYOokikDMyWKCCYrG9wH9v8As8-ehQ</recordid><startdate>20230615</startdate><enddate>20230615</enddate><creator>Henry, Melissa</creator><creator>Harvey, Raphaële</creator><creator>Chen, Lawrence M.</creator><creator>Meaney, Michael</creator><creator>Nguyen, Thi Thu Thao</creator><creator>Kao, Han-Tin</creator><creator>Rosberger, Zeev</creator><creator>Frenkiel, Saul</creator><creator>Hier, Michael</creator><creator>Zeitouni, Anthony</creator><creator>Kost, Karen</creator><creator>Mlynarek, Alex</creator><creator>Richardson, Keith</creator><creator>Greenwood, Celia M.T.</creator><creator>Melnychuk, David</creator><creator>Gold, Phil</creator><creator>Chartier, Gabrielle</creator><creator>Black, Martin</creator><creator>Mascarella, Marco</creator><creator>MacDonald, Christina</creator><creator>Sadeghi, Nader</creator><creator>Sultanem, Khalil</creator><creator>Shenouda, Georges</creator><creator>Cury, Fabio</creator><creator>O'Donnell, Kieran John</creator><general>Elsevier B.V</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20230615</creationdate><title>Genetic predisposition to depression and inflammation impacts symptom burden and survival in patients with head and neck cancer: A longitudinal study</title><author>Henry, Melissa ; Harvey, Raphaële ; Chen, Lawrence M. ; Meaney, Michael ; Nguyen, Thi Thu Thao ; Kao, Han-Tin ; Rosberger, Zeev ; Frenkiel, Saul ; Hier, Michael ; Zeitouni, Anthony ; Kost, Karen ; Mlynarek, Alex ; Richardson, Keith ; Greenwood, Celia M.T. ; Melnychuk, David ; Gold, Phil ; Chartier, Gabrielle ; Black, Martin ; Mascarella, Marco ; MacDonald, Christina ; Sadeghi, Nader ; Sultanem, Khalil ; Shenouda, Georges ; Cury, Fabio ; O'Donnell, Kieran John</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c396t-e53d8ccf99998134aab43e99fe97fbada087c3893bfc5e63c5d931cf95f609693</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Adult</topic><topic>Anxiety - genetics</topic><topic>Anxiety - psychology</topic><topic>Cancer</topic><topic>Depression</topic><topic>Depression - diagnosis</topic><topic>Depression - genetics</topic><topic>Early detection</topic><topic>Genetic Predisposition to Disease - genetics</topic><topic>Genetics</topic><topic>Head and neck cancer</topic><topic>Head and Neck Neoplasms - genetics</topic><topic>Humans</topic><topic>Inflammation</topic><topic>Inflammation - genetics</topic><topic>Longitudinal Studies</topic><topic>Oncology</topic><topic>Polygenic risk score</topic><topic>Prevention</topic><topic>Prospective Studies</topic><topic>Survival</topic><topic>Symptom burden</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Henry, Melissa</creatorcontrib><creatorcontrib>Harvey, Raphaële</creatorcontrib><creatorcontrib>Chen, Lawrence M.</creatorcontrib><creatorcontrib>Meaney, Michael</creatorcontrib><creatorcontrib>Nguyen, Thi Thu Thao</creatorcontrib><creatorcontrib>Kao, Han-Tin</creatorcontrib><creatorcontrib>Rosberger, Zeev</creatorcontrib><creatorcontrib>Frenkiel, Saul</creatorcontrib><creatorcontrib>Hier, Michael</creatorcontrib><creatorcontrib>Zeitouni, Anthony</creatorcontrib><creatorcontrib>Kost, Karen</creatorcontrib><creatorcontrib>Mlynarek, Alex</creatorcontrib><creatorcontrib>Richardson, Keith</creatorcontrib><creatorcontrib>Greenwood, Celia M.T.</creatorcontrib><creatorcontrib>Melnychuk, David</creatorcontrib><creatorcontrib>Gold, Phil</creatorcontrib><creatorcontrib>Chartier, Gabrielle</creatorcontrib><creatorcontrib>Black, Martin</creatorcontrib><creatorcontrib>Mascarella, Marco</creatorcontrib><creatorcontrib>MacDonald, Christina</creatorcontrib><creatorcontrib>Sadeghi, Nader</creatorcontrib><creatorcontrib>Sultanem, Khalil</creatorcontrib><creatorcontrib>Shenouda, Georges</creatorcontrib><creatorcontrib>Cury, Fabio</creatorcontrib><creatorcontrib>O'Donnell, Kieran John</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of affective disorders</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Henry, Melissa</au><au>Harvey, Raphaële</au><au>Chen, Lawrence M.</au><au>Meaney, Michael</au><au>Nguyen, Thi Thu Thao</au><au>Kao, Han-Tin</au><au>Rosberger, Zeev</au><au>Frenkiel, Saul</au><au>Hier, Michael</au><au>Zeitouni, Anthony</au><au>Kost, Karen</au><au>Mlynarek, Alex</au><au>Richardson, Keith</au><au>Greenwood, Celia M.T.</au><au>Melnychuk, David</au><au>Gold, Phil</au><au>Chartier, Gabrielle</au><au>Black, Martin</au><au>Mascarella, Marco</au><au>MacDonald, Christina</au><au>Sadeghi, Nader</au><au>Sultanem, Khalil</au><au>Shenouda, Georges</au><au>Cury, Fabio</au><au>O'Donnell, Kieran John</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Genetic predisposition to depression and inflammation impacts symptom burden and survival in patients with head and neck cancer: A longitudinal study</atitle><jtitle>Journal of affective disorders</jtitle><addtitle>J Affect Disord</addtitle><date>2023-06-15</date><risdate>2023</risdate><volume>331</volume><spage>149</spage><epage>157</epage><pages>149-157</pages><issn>0165-0327</issn><eissn>1573-2517</eissn><abstract>The primary purpose of this study was to investigate the contribution of genetic predispositions to depression and inflammation, as measured through polygenic risk scores, on symptom burden (physical and psychological) in patients with head and neck cancer in the immediate post-treatment period (i.e., at three months post-diagnosis), as well as on 3-, 6-, 12-, 24- and 36-month survival.
Prospective longitudinal study of 223 adults (72 % participation) newly diagnosed with a first occurrence of primary head and neck cancer, paired with genetic data (Illumina PsychArray), validated psychometric measures, Structured Clinical Interviews for DSM Disorders (SCID-I), and medical chart reviews.
Symptom burden at 3 months was predicted by (R2 adj. = 0.38, p < 0.001): a baseline SCID-I Anxiety Disorder (b = 1.69, B = 0.23, 95%CI = 0.43–2.94; p = 0.009), baseline levels of HADS anxiety (b = 0.20, B = 0.29, 95%CI = 0.07–0.34; p = 0.003), the polygenic risk score (PRS) for depression (b = 0.66, B = 0.18, 95%CI = 0.003–1.32; p = 0.049), and cumulated dose of radiotherapy (b = 0.002, B = 0.46, 95%CI = 0.001–0.003; p < 0.001). When controlling for factors known to be associated with cancer survival, patients with a higher PRS associated with depression and inflammation, respectively, presented higher risk of death within 36 months (b = 1.75, Exp(B) = 5.75, 95%CI = 1.55–21.27, p = 0.009 and b = 0.14, Exp(B) = 1.15, 95%CI = 1.01–1.30, p = 0.03).
Our results outline three potential pathways of symptom burden in patients with head and neck cancer: a genetic predisposition towards depression; an initial anxiety disorder upon being diagnosed with cancer or high levels of anxiety upon diagnosis; and a dose-related response to radiotherapy. One may want to investigate early interventions in these areas to alleviate symptom burden in patients faced with a life-threatening disease, as well as consider targeting genetic predisposition towards depression and inflammation implicated in survival. The high prevalence of distress in patients with head and neck cancer is an opportunity to study genetic predispositions, which could potentially be broadly generalized to other cancers and diseases.
•Our results outline three pathways of symptom burden in head and neck cancer: a genetic predisposition towards depression; an initial anxiety disorder upon cancer diagnosis or high anxiety levels upon diagnosis; and a dose-related response to radiotherapy.•A genetic predisposition for depression significantly predicts 3-year survival in head and neck cancer.•One warrants investigating early interventions in these areas to alleviate symptom burden in patients faced with a life-threatening disease, as well as consider targeting genetic predisposition towards depression and inflammation implicated in survival.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>36948466</pmid><doi>10.1016/j.jad.2023.03.007</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of affective disorders, 2023-06, Vol.331, p.149-157 |
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| subjects | Adult Anxiety - genetics Anxiety - psychology Cancer Depression Depression - diagnosis Depression - genetics Early detection Genetic Predisposition to Disease - genetics Genetics Head and neck cancer Head and Neck Neoplasms - genetics Humans Inflammation Inflammation - genetics Longitudinal Studies Oncology Polygenic risk score Prevention Prospective Studies Survival Symptom burden |
| title | Genetic predisposition to depression and inflammation impacts symptom burden and survival in patients with head and neck cancer: A longitudinal study |
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