Anti-inflammatory medication use associated with reduced delirium risk and all-cause mortality: A retrospective cohort study

To investigate the relationship between history of anti-inflammatory medication use and delirium risk, as well as long-term mortality. In this retrospective cohort study, subjects recruited between January 2016 and March 2020 were analyzed. Information about anti-inflammatory medication use history...

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Published in:Journal of psychosomatic research 2023-05, Vol.168, p.111212-111212, Article 111212
Main Authors: Yamanashi, Takehiko, Sullivan, Eleanor J., Comp, Katie R., Nishizawa, Yoshitaka, Akers, Cade C., Chang, Gloria, Modukuri, Manisha, Tran, Tammy, Anderson, Zoe-Ella E.M., Marra, Pedro S., Crutchley, Kaitlyn J., Wahba, Nadia E., Iwata, Masaaki, Karam, Matthew D., Noiseux, Nicolas O., Cho, Hyunkeun R., Shinozaki, Gen
Format: Article
Language:English
Subjects:
Anti-Inflammatory Agents, Non-Steroidal - adverse effects
Anti-inflammatory medication
Aspirin - therapeutic use
Delirium
Delirium - complications
Delirium - epidemiology
Glucosamine
Humans
Mortality
NSAIDs
Proportional Hazards Models
Retrospective Studies
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Summary:To investigate the relationship between history of anti-inflammatory medication use and delirium risk, as well as long-term mortality. In this retrospective cohort study, subjects recruited between January 2016 and March 2020 were analyzed. Information about anti-inflammatory medication use history including aspirin, NSAIDs, glucosamine, and other anti-inflammatory drugs, was collected. Logistic regression analysis investigated the relationship between anti-inflammatory medications and delirium. Log-rank analysis and cox proportional hazards model investigated the relationship between anti-inflammatory medications and one-year mortality. The data from 1274 subjects were analyzed. The prevalence of delirium was significantly lower in subjects with NSAIDs usage (23.0%) than in those without NSAIDs usage (35.0%) (p 
ISSN:0022-3999
1879-1360
DOI:10.1016/j.jpsychores.2023.111212