Adaptive living skills, sleep problems, and mental health disorders in adults with 22q11.21 deletion syndrome

• Published in: Research in developmental disabilities 2023-05, Vol.136, p.104491-104491, Article 104491
• Main Authors: Leader, Geraldine, Curtin, Andrea, Shprintzen, Robert J., Whelan, Sally, Coyne, Rory, Mannion, Arlene
• Format: Article
• Language: English
• Subjects: 22q11 Deletion Syndrome; Activities of Daily Living; Adult; Conotruncal anomaly face syndrome; DiGeorge syndrome; DiGeorge Syndrome - complications; DiGeorge Syndrome - epidemiology; DiGeorge Syndrome - genetics; Humans; Mental Disorders - epidemiology; Mental Disorders - genetics; Mental Health; Sedlačková syndrome; Sleep Wake Disorders - epidemiology; Sleep Wake Disorders - genetics; Velo-cardio-facial syndrome
• ISSN: 0891-4222; 1873-3379
• DOI: 10.1016/j.ridd.2023.104491

22q11.21 deletion syndrome (22q11DS) is a neurodevelopmental syndrome caused by a microdeletion of genes at the 22q11.21 locus. It has a prevalence of 1:2000. This study investigated the prevalence of adaptive living skills, sleep problems, and mental health disorders in adults with 22q11DS and examined the relationship between these factors. Parents with an adult son or daughter with 22q11DS completed the following: A bespoke Demographic Information Questionnaire, Sleep Questionnaire (SQ-SP), Psychopathology in Autism Checklist (PAC), and Activities of Daily Living (ADL) scale. Descriptive statistics, correlations, and one-way between groups analysis of variance (ANOVA) were conducted. Mental health difficulties, sleep problems, and low levels of adaptive living skills are prevalent in adults with 22q11DS. Strong positive correlations were identified between sleep problems, depression, and anxiety subscale scores and moderate negative correlations between depression, psychosis, and activities of daily living skills. Adults with 22q11DS need screening and treatment for mental health and sleep problems. •Adults with 22q11.21DS commonly have mental health and sleep problems.•Sleep problems, depression, and anxiety are strongly related in 22q11.2DS.•Depression, and daily living activities are moderately correlated in 22q11. DS.