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Cardiac hypertrophy simulations using parametric and echocardiography-based left ventricle model with shell finite elements
In our paper, we simulated cardiac hypertrophy with the use of shell elements in parametric and echocardiography-based left ventricle (LV) models. The hypertrophy has an impact on the change in the wall thickness, displacement field and the overall functioning of the heart. We computed both eccentri...
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Published in: | Computers in biology and medicine 2023-05, Vol.157, p.106742-106742, Article 106742 |
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Main Authors: | , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites |
Online Access: | Get full text |
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Summary: | In our paper, we simulated cardiac hypertrophy with the use of shell elements in parametric and echocardiography-based left ventricle (LV) models. The hypertrophy has an impact on the change in the wall thickness, displacement field and the overall functioning of the heart. We computed both eccentric and concentric hypertrophy effects and tracked changes in the ventricle shape and wall thickness. Thickening of the wall was developed under the influence of concentric hypertrophy, while the eccentric hypertrophy produces wall thinning. To model passive stresses we used the recently developed material modal based on the Holzapfel experiments. Also, our specific shell composite finite element models for heart mechanics are much smaller and simpler to use with respect to conventional 3D models. Furthermore, the presented modeling approach of the echocardiography-based LV can serve as the basis for practical applications since it relies on the true patient-specific geometry and experimental constitutive relationships. Our model gives an insight into hypertrophy development in realistic heart geometries, and it has the potential to test medical hypotheses regarding hypertrophy evolution in a healthy and heart with a disease, under the influence of different conditions and parameters.
The main contributions of our research include:•Easier and more efficient modeling of the left ventricle mechanics, based on the use of our shell composite finite elements.•The computational models provide changes in the wall thickness over time and the shape evolution of the ventricle.•The models can be used to track hypertrophy disease progression.•The echocardiography-based model relies on the motion of the internal LV surface.•Our models can be employed as the basis of an expert system in medical applications. |
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ISSN: | 0010-4825 1879-0534 |
DOI: | 10.1016/j.compbiomed.2023.106742 |