Drug-repurposing screen on patient-derived organoids identifies therapy-induced vulnerability in KRAS-mutant colon cancer

Patient-derived organoids (PDOs) are widely heralded as a drug-screening platform to develop new anti-cancer therapies. Here, we use a drug-repurposing library to screen PDOs of colorectal cancer (CRC) to identify hidden vulnerabilities within therapy-induced phenotypes. Using a microscopy-based scr...

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Bibliographic Details
Published in:	Cell reports (Cambridge) 2023-04, Vol.42 (4), p.112324, Article 112324
Main Authors:	Mertens, Sander, Huismans, Maarten A., Verissimo, Carla S., Ponsioen, Bas, Overmeer, Rene, Proost, Natalie, van Tellingen, Olaf, van de Ven, Marieke, Begthel, Harry, Boj, Sylvia F., Clevers, Hans, Roodhart, Jeanine M.L., Bos, Johannes L., Snippert, Hugo J.G.
Format:	Article
Language:	English
Subjects:	colorectal cancer CP: Cancer CP: Stem cell research image-based drug screening microtubule-targeting agents organoids targeted therapy
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