Does lymphovascular invasion predict survival in oral cancer? A population-based analysis

•Lymphovascular invasion occurs in 20% of oral cavity squamous cell carcinomas.•Lymphovascular invasion predicted reduced two- and five-year survival rates.•Addition of chemoradiotherapy to surgery improves survival rates in these patients. To evaluate lymphovascular invasion as an independent predi...

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Bibliographic Details
Published in:Oral oncology 2023-05, Vol.140, p.106387-106387, Article 106387
Main Authors: Comer, Julia C., Harris, Andrew B., Hess, Andrew O., Hitchcock, Kathryn E., Mendenhall, William M., Bates, James E., Dziegielewski, Peter T.
Format: Article
Language:English
Subjects:
Carcinoma, Squamous Cell - pathology
Head and Neck Neoplasms - pathology
Humans
Lymphovascular invasion
Mouth Neoplasms - pathology
National Cancer Database
Neoplasm Invasiveness - pathology
Neoplasm Staging
Oral cancer
Overall survival
Prognosis
Retrospective Studies
Squamous Cell Carcinoma of Head and Neck - pathology
Survival Analysis
United States
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Summary:•Lymphovascular invasion occurs in 20% of oral cavity squamous cell carcinomas.•Lymphovascular invasion predicted reduced two- and five-year survival rates.•Addition of chemoradiotherapy to surgery improves survival rates in these patients. To evaluate lymphovascular invasion as an independent predictor for overall survival in patients with oral cavity squamous cell carcinoma. Retrospective cohort study. Multi-center, population-based facilities reporting to the National Cancer Database registry. The database was accessed to collect data on patients with oral cavity squamous cell carcinoma. A multivariate cox proportional hazards model was used to analyze the association between presence of lymphovascular invasion and overall survival. 16,992 patients met inclusion criteria. 3,457 patients had lymphovascular invasion. The mean follow-up was 32 ± 19 months. Lymphovascular invasion predicted reduced 2-year overall survival (relative hazard 1.29, 95% CI: 1.20, 1.38, p 
ISSN:1368-8375
1879-0593
DOI:10.1016/j.oraloncology.2023.106387