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Does lymphovascular invasion predict survival in oral cancer? A population-based analysis
•Lymphovascular invasion occurs in 20% of oral cavity squamous cell carcinomas.•Lymphovascular invasion predicted reduced two- and five-year survival rates.•Addition of chemoradiotherapy to surgery improves survival rates in these patients. To evaluate lymphovascular invasion as an independent predi...
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| Published in: | Oral oncology 2023-05, Vol.140, p.106387-106387, Article 106387 |
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| container_end_page | 106387 |
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| container_start_page | 106387 |
| container_title | Oral oncology |
| container_volume | 140 |
| creator | Comer, Julia C. Harris, Andrew B. Hess, Andrew O. Hitchcock, Kathryn E. Mendenhall, William M. Bates, James E. Dziegielewski, Peter T. |
| description | •Lymphovascular invasion occurs in 20% of oral cavity squamous cell carcinomas.•Lymphovascular invasion predicted reduced two- and five-year survival rates.•Addition of chemoradiotherapy to surgery improves survival rates in these patients.
To evaluate lymphovascular invasion as an independent predictor for overall survival in patients with oral cavity squamous cell carcinoma.
Retrospective cohort study.
Multi-center, population-based facilities reporting to the National Cancer Database registry.
The database was accessed to collect data on patients with oral cavity squamous cell carcinoma. A multivariate cox proportional hazards model was used to analyze the association between presence of lymphovascular invasion and overall survival.
16,992 patients met inclusion criteria. 3,457 patients had lymphovascular invasion. The mean follow-up was 32 ± 19 months. Lymphovascular invasion predicted reduced 2-year overall survival (relative hazard 1.29, 95% CI: 1.20, 1.38, p |
| doi_str_mv | 10.1016/j.oraloncology.2023.106387 |
| format | article |
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To evaluate lymphovascular invasion as an independent predictor for overall survival in patients with oral cavity squamous cell carcinoma.
Retrospective cohort study.
Multi-center, population-based facilities reporting to the National Cancer Database registry.
The database was accessed to collect data on patients with oral cavity squamous cell carcinoma. A multivariate cox proportional hazards model was used to analyze the association between presence of lymphovascular invasion and overall survival.
16,992 patients met inclusion criteria. 3,457 patients had lymphovascular invasion. The mean follow-up was 32 ± 19 months. Lymphovascular invasion predicted reduced 2-year overall survival (relative hazard 1.29, 95% CI: 1.20, 1.38, p < 0.001) and 5-year overall survival (relative hazard 1.30, 95% CI: 1.23, 1.39, p < 0.001). LVI reduced overall survival in patients with squamous cell carcinoma of the oral tongue (HR: 1.27, 95% CI: 1.17, 1.39, p < 0.001), floor of mouth (HR: 1.33, 95% CI: 1.17, 1.52, p < 0.001) and buccal mucosa (HR: 1.44, 95% CI: 1.15, 1.81, p = 0.001). Patients with lymphovascular invasion treated with surgery plus post-operative radiotherapy had significantly improved survival compared to those who underwent surgery alone (relative hazard 1.79, 95% CI: 1.58, 2.03, p < 0.001), and patients treated with surgery + post-operative chemoradiotherapy had improved survival compared to those treated with surgery alone (relative hazard 2.0, 95% CI: 2.26, 1.79, p < 0.001).
Lymphovascular invasion is an important independent risk factor for decreased overall survival in oral cavity squamous cell carcinoma involving the oral tongue, floor of mouth and buccal mucosa subsites.]]></description><identifier>ISSN: 1368-8375</identifier><identifier>EISSN: 1879-0593</identifier><identifier>DOI: 10.1016/j.oraloncology.2023.106387</identifier><identifier>PMID: 37011428</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Carcinoma, Squamous Cell - pathology ; Head and Neck Neoplasms - pathology ; Humans ; Lymphovascular invasion ; Mouth Neoplasms - pathology ; National Cancer Database ; Neoplasm Invasiveness - pathology ; Neoplasm Staging ; Oral cancer ; Overall survival ; Prognosis ; Retrospective Studies ; Squamous Cell Carcinoma of Head and Neck - pathology ; Survival Analysis ; United States</subject><ispartof>Oral oncology, 2023-05, Vol.140, p.106387-106387, Article 106387</ispartof><rights>2023 Elsevier Ltd</rights><rights>Copyright © 2023 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c380t-9f3b959264637e68c1c18abd536132b3660ba2ce92c4d78e12cdbc79528547343</citedby><cites>FETCH-LOGICAL-c380t-9f3b959264637e68c1c18abd536132b3660ba2ce92c4d78e12cdbc79528547343</cites><orcidid>0000-0003-2244-8204</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37011428$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Comer, Julia C.</creatorcontrib><creatorcontrib>Harris, Andrew B.</creatorcontrib><creatorcontrib>Hess, Andrew O.</creatorcontrib><creatorcontrib>Hitchcock, Kathryn E.</creatorcontrib><creatorcontrib>Mendenhall, William M.</creatorcontrib><creatorcontrib>Bates, James E.</creatorcontrib><creatorcontrib>Dziegielewski, Peter T.</creatorcontrib><title>Does lymphovascular invasion predict survival in oral cancer? A population-based analysis</title><title>Oral oncology</title><addtitle>Oral Oncol</addtitle><description><![CDATA[•Lymphovascular invasion occurs in 20% of oral cavity squamous cell carcinomas.•Lymphovascular invasion predicted reduced two- and five-year survival rates.•Addition of chemoradiotherapy to surgery improves survival rates in these patients.
To evaluate lymphovascular invasion as an independent predictor for overall survival in patients with oral cavity squamous cell carcinoma.
Retrospective cohort study.
Multi-center, population-based facilities reporting to the National Cancer Database registry.
The database was accessed to collect data on patients with oral cavity squamous cell carcinoma. A multivariate cox proportional hazards model was used to analyze the association between presence of lymphovascular invasion and overall survival.
16,992 patients met inclusion criteria. 3,457 patients had lymphovascular invasion. The mean follow-up was 32 ± 19 months. Lymphovascular invasion predicted reduced 2-year overall survival (relative hazard 1.29, 95% CI: 1.20, 1.38, p < 0.001) and 5-year overall survival (relative hazard 1.30, 95% CI: 1.23, 1.39, p < 0.001). LVI reduced overall survival in patients with squamous cell carcinoma of the oral tongue (HR: 1.27, 95% CI: 1.17, 1.39, p < 0.001), floor of mouth (HR: 1.33, 95% CI: 1.17, 1.52, p < 0.001) and buccal mucosa (HR: 1.44, 95% CI: 1.15, 1.81, p = 0.001). Patients with lymphovascular invasion treated with surgery plus post-operative radiotherapy had significantly improved survival compared to those who underwent surgery alone (relative hazard 1.79, 95% CI: 1.58, 2.03, p < 0.001), and patients treated with surgery + post-operative chemoradiotherapy had improved survival compared to those treated with surgery alone (relative hazard 2.0, 95% CI: 2.26, 1.79, p < 0.001).
Lymphovascular invasion is an important independent risk factor for decreased overall survival in oral cavity squamous cell carcinoma involving the oral tongue, floor of mouth and buccal mucosa subsites.]]></description><subject>Carcinoma, Squamous Cell - pathology</subject><subject>Head and Neck Neoplasms - pathology</subject><subject>Humans</subject><subject>Lymphovascular invasion</subject><subject>Mouth Neoplasms - pathology</subject><subject>National Cancer Database</subject><subject>Neoplasm Invasiveness - pathology</subject><subject>Neoplasm Staging</subject><subject>Oral cancer</subject><subject>Overall survival</subject><subject>Prognosis</subject><subject>Retrospective Studies</subject><subject>Squamous Cell Carcinoma of Head and Neck - pathology</subject><subject>Survival Analysis</subject><subject>United States</subject><issn>1368-8375</issn><issn>1879-0593</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNqNkE1LAzEURYMoVqt_QYIrN1PzMZPJuBFp_YKCG124CpnMq6akkzGZKfTfm9IqLl3lwTs3l3cQuqRkQgkV18uJD9r51njnPzYTRhhPC8FleYBOqCyrjBQVP0wzFzKTvCxG6DTGJSGkoAU5RiNeEkpzJk_Q-8xDxG6z6j79WkczOB2wbdNofYu7AI01PY5DWNu1dmmDt93Y6NZAuMV3uPNdyvSJzmodocG61W4TbTxDRwvtIpzv3zF6e7h_nT5l85fH5-ndPDNckj6rFryuioqJXPAShDTUUKnrpuCCclZzIUitmYGKmbwpJVBmmtqUVcFkkZc852N0tfu3C_5rgNirlY0GnNMt-CEqllgukqMterNDTfAxBlioLtiVDhtFidqqVUv1V63aqlU7tSl8se8Z6hU0v9EflwmY7QBI164tBBWNheSpsQFMrxpv_9PzDQQ7kg4</recordid><startdate>202305</startdate><enddate>202305</enddate><creator>Comer, Julia C.</creator><creator>Harris, Andrew B.</creator><creator>Hess, Andrew O.</creator><creator>Hitchcock, Kathryn E.</creator><creator>Mendenhall, William M.</creator><creator>Bates, James E.</creator><creator>Dziegielewski, Peter T.</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-2244-8204</orcidid></search><sort><creationdate>202305</creationdate><title>Does lymphovascular invasion predict survival in oral cancer? A population-based analysis</title><author>Comer, Julia C. ; Harris, Andrew B. ; Hess, Andrew O. ; Hitchcock, Kathryn E. ; Mendenhall, William M. ; Bates, James E. ; Dziegielewski, Peter T.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c380t-9f3b959264637e68c1c18abd536132b3660ba2ce92c4d78e12cdbc79528547343</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Carcinoma, Squamous Cell - pathology</topic><topic>Head and Neck Neoplasms - pathology</topic><topic>Humans</topic><topic>Lymphovascular invasion</topic><topic>Mouth Neoplasms - pathology</topic><topic>National Cancer Database</topic><topic>Neoplasm Invasiveness - pathology</topic><topic>Neoplasm Staging</topic><topic>Oral cancer</topic><topic>Overall survival</topic><topic>Prognosis</topic><topic>Retrospective Studies</topic><topic>Squamous Cell Carcinoma of Head and Neck - pathology</topic><topic>Survival Analysis</topic><topic>United States</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Comer, Julia C.</creatorcontrib><creatorcontrib>Harris, Andrew B.</creatorcontrib><creatorcontrib>Hess, Andrew O.</creatorcontrib><creatorcontrib>Hitchcock, Kathryn E.</creatorcontrib><creatorcontrib>Mendenhall, William M.</creatorcontrib><creatorcontrib>Bates, James E.</creatorcontrib><creatorcontrib>Dziegielewski, Peter T.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Oral oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Comer, Julia C.</au><au>Harris, Andrew B.</au><au>Hess, Andrew O.</au><au>Hitchcock, Kathryn E.</au><au>Mendenhall, William M.</au><au>Bates, James E.</au><au>Dziegielewski, Peter T.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Does lymphovascular invasion predict survival in oral cancer? A population-based analysis</atitle><jtitle>Oral oncology</jtitle><addtitle>Oral Oncol</addtitle><date>2023-05</date><risdate>2023</risdate><volume>140</volume><spage>106387</spage><epage>106387</epage><pages>106387-106387</pages><artnum>106387</artnum><issn>1368-8375</issn><eissn>1879-0593</eissn><abstract><![CDATA[•Lymphovascular invasion occurs in 20% of oral cavity squamous cell carcinomas.•Lymphovascular invasion predicted reduced two- and five-year survival rates.•Addition of chemoradiotherapy to surgery improves survival rates in these patients.
To evaluate lymphovascular invasion as an independent predictor for overall survival in patients with oral cavity squamous cell carcinoma.
Retrospective cohort study.
Multi-center, population-based facilities reporting to the National Cancer Database registry.
The database was accessed to collect data on patients with oral cavity squamous cell carcinoma. A multivariate cox proportional hazards model was used to analyze the association between presence of lymphovascular invasion and overall survival.
16,992 patients met inclusion criteria. 3,457 patients had lymphovascular invasion. The mean follow-up was 32 ± 19 months. Lymphovascular invasion predicted reduced 2-year overall survival (relative hazard 1.29, 95% CI: 1.20, 1.38, p < 0.001) and 5-year overall survival (relative hazard 1.30, 95% CI: 1.23, 1.39, p < 0.001). LVI reduced overall survival in patients with squamous cell carcinoma of the oral tongue (HR: 1.27, 95% CI: 1.17, 1.39, p < 0.001), floor of mouth (HR: 1.33, 95% CI: 1.17, 1.52, p < 0.001) and buccal mucosa (HR: 1.44, 95% CI: 1.15, 1.81, p = 0.001). Patients with lymphovascular invasion treated with surgery plus post-operative radiotherapy had significantly improved survival compared to those who underwent surgery alone (relative hazard 1.79, 95% CI: 1.58, 2.03, p < 0.001), and patients treated with surgery + post-operative chemoradiotherapy had improved survival compared to those treated with surgery alone (relative hazard 2.0, 95% CI: 2.26, 1.79, p < 0.001).
Lymphovascular invasion is an important independent risk factor for decreased overall survival in oral cavity squamous cell carcinoma involving the oral tongue, floor of mouth and buccal mucosa subsites.]]></abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>37011428</pmid><doi>10.1016/j.oraloncology.2023.106387</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0003-2244-8204</orcidid></addata></record> |
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| source | Elsevier |
| subjects | Carcinoma, Squamous Cell - pathology Head and Neck Neoplasms - pathology Humans Lymphovascular invasion Mouth Neoplasms - pathology National Cancer Database Neoplasm Invasiveness - pathology Neoplasm Staging Oral cancer Overall survival Prognosis Retrospective Studies Squamous Cell Carcinoma of Head and Neck - pathology Survival Analysis United States |
| title | Does lymphovascular invasion predict survival in oral cancer? A population-based analysis |
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