Decision Regret among Patients with Early-stage Lung Cancer Undergoing Radiation Therapy or Surgical Resection

• Published in: Clinical oncology (Royal College of Radiologists (Great Britain)) 2023-06, Vol.35 (6), p.e352-e361
• Main Authors: Sullivan, D.R., Wisnivesky, J.P., Nugent, S.M., Stone, K., Farris, M.K., Kern, J.A., Swanson, S., Smith, C.B., Rosenzweig, K., Slatore, C.G.
• Format: Article
• Language: English
• Subjects: Aged; Carcinoma, Non-Small-Cell Lung - pathology; Carcinoma, Non-Small-Cell Lung - radiotherapy; Carcinoma, Non-Small-Cell Lung - surgery; Decision making; depression; Emotions; Female; Humans; lung neoplasms; Lung Neoplasms - pathology; Lung Neoplasms - radiotherapy; Lung Neoplasms - surgery; Male; Neoplasm Staging; Prospective Studies; quality of life; radiation; Radiosurgery - adverse effects; thoracic surgery; Treatment Outcome
• ISSN: 0936-6555; 1433-2981
• DOI: 10.1016/j.clon.2023.03.015

Clinical equipoise exists regarding early-stage lung cancer treatment among patients as trials comparing stereotactic body radiation therapy (SBRT) and surgical resection are unavailable. Given the potential differences in treatment effectiveness and side-effects, we sought to determine the associations between treatment type, decision regret and depression. A multicentre, prospective study of patients with stage IA–IIA non-small cell lung cancer (NSCLC) with planned treatment with SBRT or surgical resection was conducted. Decision regret and depression were measured using the Decision Regret Scale (DRS) and Patient Health Questionnaire-4 (PHQ-4) at 3, 6 and 12 months post-treatment, respectively. Mixed linear regression modelling examined associations between treatment and decision regret adjusting for patient sociodemographics. Among 211 study participants with early-stage lung cancer, 128 (61%) patients received SBRT and 83 (39%) received surgical resection. The mean age was 73 years (standard deviation = 8); 57% were female; 79% were White non-Hispanic. In the entire cohort at 3 months post-treatment, 72 (34%) and 57 (27%) patients had mild and severe decision regret, respectively. Among patients who received SBRT or surgery, 71% and 46% of patients experienced at least mild decision regret at 3 months, respectively. DRS scores increased at 6 months and decreased slightly at 12 months of follow-up in both groups. Higher DRS scores were associated with SBRT treatment (adjusted mean difference = 4.18, 95% confidence interval 0.82 to 7.54) and depression (adjusted mean difference = 3.49, 95% confidence interval 0.52 to 6.47). Neither patient satisfaction with their provider nor decision-making role concordance was associated with DRS scores. Most early-stage lung cancer patients experienced at least mild decision regret, which was associated with SBRT treatment and depression symptoms. Findings suggest patients with early-stage lung cancer may not be receiving optimal treatment decision-making support. Therefore, opportunities for improved patient–clinician communication probably exist. •Early-stage lung cancer patients have high decision regret levels after treatment.•One in four early-stage lung cancer patients has severe levels of decision regret.•Radiation therapy and depression are associated with increased decision regret.•Lung cancer patients may not be receiving optimal treatment decision-making support.